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Title:
Improved Ultrafiltration Method to Measure Drug Release from Nanomedicines Utilizing a Stable Isotope Tracer | SpringerLink
Description:
An important step in the early development of a nanomedicine formulation is the evaluation of stability and drug release in biological matrices. Additionally, the measurement of encapsulated and unencapsulated nanomedicine drug fractions is important for the...
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Keywords {🔍}

drug, research, release, protocol, content, measure, stern, nanomedicine, protein, chapter, privacy, cookies, information, publish, characterization, delivery, methods, encapsulated, plasma, article, springer, cancer, data, search, nanoparticles, ultrafiltration, method, nanomedicines, stable, isotope, skoczen, binding, access, google, scholar, pubmed, download, national, laboratory, frederick, usd, personal, log, journal, intended, tracer, stephan, book, unencapsulated, fractions,

Topics {✒️}

month download article/chapter springer international publishing existing ultrafiltration protocols privacy choices/manage cookies improved ultrafiltration method device instant download stable isotope tracer stable isotope method nanotechnology characterization laboratory leidos biomedical research fundamental disadvantages including author information authors editor information editors drug delivery systems european economic area process-induced artifacts time-dependent manner de vlieger jsb organizations imply endorsement protein-bound fractions journal finder publish drug delivery sarah national cancer institute measure drug release tissue binding data conditions privacy policy accepting optional cookies frederick national laboratory biological complex drugs main content log social media permissions reprints cancer research plasma protein binding protocol usd 49 check access nbcd pharmacokinetics ethics access commercial products protocol characterization unencapsulated drug drug delivery protocol skoczen humana press protocol cite journal publish privacy policy mcneil rights drug release current ultrafiltration

Schema {🗺️}

ScholarlyArticle:
      headline:Improved Ultrafiltration Method to Measure Drug Release from Nanomedicines Utilizing a Stable Isotope Tracer
      pageEnd:239
      pageStart:223
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-7352-1.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Characterization of Nanoparticles Intended for Drug Delivery
         isbn:
            978-1-4939-7352-1
            978-1-4939-7350-7
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sarah L. Skoczen
            affiliation:
                  name:Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
                  address:
                     name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stephan T. Stern
            affiliation:
                  name:Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
                  address:
                     name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Nanomedicine, Drug release, Stability, Stable isotope, Bioanalytical
      description:An important step in the early development of a nanomedicine formulation is the evaluation of stability and drug release in biological matrices. Additionally, the measurement of encapsulated and unencapsulated nanomedicine drug fractions is important for the determination of bioequivalence (pharmacokinetic equivalence) of generic nanomedicines. Unfortunately, current methods to measure drug release in plasma are limited, and all have fundamental disadvantages including non-equilibrium conditions and process-induced artifacts. The primary limitation of current ultrafiltration (and equilibrium dialysis) methods for separation of encapsulated and unencapsulated drug and determination of drug release is the difficulty in accurately differentiating protein bound and encapsulated drug. Since the protein binding of most drugs is high (>70%) and can change in a concentration- and time-dependent manner, it is very difficult to accurately account for the fraction of non-filterable drug that is encapsulated within the nanomedicine and how much is bound to protein. The method in this chapter is an improvement of existing ultrafiltration protocols for nanomedicine fractionation in plasma, in which a stable isotope tracer is spiked into a nanomedicine containing plasma sample in order to precisely measure the degree of plasma protein binding. Determination of protein binding then allows for accurate calculation of encapsulated and unencapsulated nanomedicine drug fractions, as well as free and protein-bound fractions.
      datePublished:2018
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Book:
      name:Characterization of Nanoparticles Intended for Drug Delivery
      isbn:
         978-1-4939-7352-1
         978-1-4939-7350-7
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
      address:
         name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
         type:PostalAddress
      name:Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
      address:
         name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sarah L. Skoczen
      affiliation:
            name:Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
            address:
               name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
               type:PostalAddress
            type:Organization
      name:Stephan T. Stern
      affiliation:
            name:Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
            address:
               name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
      name:Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
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