We are analyzing https://link.springer.com/protocol/10.1007/978-1-4939-7187-9_9.

Title:
Quick Detection of DNase II-Type Breaks in Formalin-Fixed Tissue Sections | SpringerLink
Description:
Blunt-ended DNase II-type breaks with 5′ hydroxyls are generated in phagocytic cells of any lineage during digestion of the engulfed DNA. These breaks indicate the ongoing active phagocytic reaction. They are produced by the acid deoxyribonuclease–DNase...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Quick Detection of DNase II-Type Breaks in Formalin-Fixed Tissue Sections
      pageEnd:119
      pageStart:113
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-7187-9.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Fast Detection of DNA Damage
         isbn:
            978-1-4939-7187-9
            978-1-4939-7185-5
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Candace L. Minchew
            affiliation:
                  name:Baylor College of Medicine
                  address:
                     name:Department of Neurosurgery, Baylor College of Medicine, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:2002 Holcombe Boulevard
                  address:
                     name:Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vladimir V. Didenko
            affiliation:
                  name:Baylor College of Medicine
                  address:
                     name:Department of Neurosurgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Phagocytic digestion of DNA, Labeling of phagocytosis, Phagolysosomes, Clearance of cell death, Express detection of DNase II cleavage, 5′ OH DNA probes
      description:Blunt-ended DNase II-type breaks with 5′ hydroxyls are generated in phagocytic cells of any lineage during digestion of the engulfed DNA. These breaks indicate the ongoing active phagocytic reaction. They are produced by the acid deoxyribonuclease–DNase II which is the primary endonuclease responsible for DNA degradation after its engulfment. Here, we present an express approach that detects blunt-ended 5′ OH DNA breaks in fixed tissue sections. The technique is simple to perform and takes only 60 min to complete. It can be useful in studies of the clearance of dying cells in oncological, inflammatory, and autoimmune disorders.
      datePublished:2017
      isAccessibleForFree:
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         type:WebPageElement
      context:https://schema.org
Book:
      name:Fast Detection of DNA Damage
      isbn:
         978-1-4939-7187-9
         978-1-4939-7185-5
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Baylor College of Medicine
      address:
         name:Department of Neurosurgery, Baylor College of Medicine, Houston, USA
         type:PostalAddress
      name:2002 Holcombe Boulevard
      address:
         name:Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, USA
         type:PostalAddress
      name:Baylor College of Medicine
      address:
         name:Department of Neurosurgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Candace L. Minchew
      affiliation:
            name:Baylor College of Medicine
            address:
               name:Department of Neurosurgery, Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
            name:2002 Holcombe Boulevard
            address:
               name:Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, USA
               type:PostalAddress
            type:Organization
      name:Vladimir V. Didenko
      affiliation:
            name:Baylor College of Medicine
            address:
               name:Department of Neurosurgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Neurosurgery, Baylor College of Medicine, Houston, USA
      name:Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, USA
      name:Department of Neurosurgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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