We are analyzing https://link.springer.com/protocol/10.1007/978-1-4939-7138-1_10.

Title:
X-Aptamer Selection and Validation | SpringerLink
Description:
Aptamers and second generation analogs, such as X-Aptamers (XAs), SOMAmers, locked nucleic acids (LNAs), and others are increasingly being used for molecular pathway targeting, biomarker discovery, or disease diagnosis by interacting with protein targets on the...
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ScholarlyArticle:
      headline:X-Aptamer Selection and Validation
      pageEnd:174
      pageStart:151
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-7138-1.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:RNA Nanostructures
         isbn:
            978-1-4939-7138-1
            978-1-4939-7137-4
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ganesh L. Lokesh
            affiliation:
                  name:The University of Texas Health Science Center
                  address:
                     name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas Health Science Center
                  address:
                     name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongyu Wang
            affiliation:
                  name:The University of Texas Health Science Center
                  address:
                     name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas Health Science Center
                  address:
                     name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Curtis H. Lam
            affiliation:
                  name:AM Biotechnologies, LLC
                  address:
                     name:AM Biotechnologies, LLC, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Varatharasa Thiviyanathan
            affiliation:
                  name:The University of Texas Health Science Center
                  address:
                     name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas Health Science Center
                  address:
                     name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nancy Ward
            affiliation:
                  name:AM Biotechnologies, LLC
                  address:
                     name:AM Biotechnologies, LLC, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David G. Gorenstein
            affiliation:
                  name:AM Biotechnologies, LLC
                  address:
                     name:AM Biotechnologies, LLC, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:David E. Volk
            affiliation:
                  name:The University of Texas Health Science Center
                  address:
                     name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas Health Science Center
                  address:
                     name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Aptamer, X-Aptamer, Molecular targeting, Biotin labeling, Dye labeling, Bead-based selection, Split-pool synthesis, Drug aptamer conjugation, Aptamer nanoparticle conjugation, Aptamer siRNA chimeras, Chemical cross-linking, Proteomics
      description:Aptamers and second generation analogs, such as X-Aptamers (XAs), SOMAmers, locked nucleic acids (LNAs), and others are increasingly being used for molecular pathway targeting, biomarker discovery, or disease diagnosis by interacting with protein targets on the surface of cells or in solution. Such targeting is being used for imaging, diagnostic evaluation, interference of protein function, or delivery of therapeutic agents. Selection of aptamers using the original SELEX method is cumbersome and time-consuming, often requiring 10–15 rounds of selection, and provides aptamers with a limited number of functional groups, namely four bases of DNA or RNA, although newer SELEX methods have increased this diversity. In contrast, X-Aptamers provide an unlimited number of functional groups and thus are superior targeting agents. Here, we discuss the X-Aptamer selection process.
      datePublished:2017
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Book:
      name:RNA Nanostructures
      isbn:
         978-1-4939-7138-1
         978-1-4939-7137-4
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The University of Texas Health Science Center
      address:
         name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:AM Biotechnologies, LLC
      address:
         name:AM Biotechnologies, LLC, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:AM Biotechnologies, LLC
      address:
         name:AM Biotechnologies, LLC, Houston, USA
         type:PostalAddress
      name:AM Biotechnologies, LLC
      address:
         name:AM Biotechnologies, LLC, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
      name:The University of Texas Health Science Center
      address:
         name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ganesh L. Lokesh
      affiliation:
            name:The University of Texas Health Science Center
            address:
               name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas Health Science Center
            address:
               name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Hongyu Wang
      affiliation:
            name:The University of Texas Health Science Center
            address:
               name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas Health Science Center
            address:
               name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Curtis H. Lam
      affiliation:
            name:AM Biotechnologies, LLC
            address:
               name:AM Biotechnologies, LLC, Houston, USA
               type:PostalAddress
            type:Organization
      name:Varatharasa Thiviyanathan
      affiliation:
            name:The University of Texas Health Science Center
            address:
               name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas Health Science Center
            address:
               name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Nancy Ward
      affiliation:
            name:AM Biotechnologies, LLC
            address:
               name:AM Biotechnologies, LLC, Houston, USA
               type:PostalAddress
            type:Organization
      name:David G. Gorenstein
      affiliation:
            name:AM Biotechnologies, LLC
            address:
               name:AM Biotechnologies, LLC, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:David E. Volk
      affiliation:
            name:The University of Texas Health Science Center
            address:
               name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas Health Science Center
            address:
               name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
      name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
      name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
      name:AM Biotechnologies, LLC, Houston, USA
      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
      name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
      name:AM Biotechnologies, LLC, Houston, USA
      name:AM Biotechnologies, LLC, Houston, USA
      name:Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center, Houston, USA
      name:Department of Nanomedicine and Biomedical Engineering, McGovern Medical School, The University of Texas Health Science Center, Houston, USA
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