We are analyzing https://link.springer.com/protocol/10.1007/978-1-4939-3625-0_17.

Title:
Transfection of Tumor-Infiltrating T Cells with mRNA Encoding CXCR2 | SpringerLink
Description:
Adoptive T-cell therapy based on the infusion of patient’s own immune cells after ex vivo culturing is among the most potent forms of personalized treatment among recent clinical developments for the treatment of cancer. However, despite high rates of...
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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Transfection of Tumor-Infiltrating T Cells with mRNA Encoding CXCR2
      pageEnd:276
      pageStart:261
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-3625-0.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Synthetic mRNA
         isbn:
            978-1-4939-3625-0
            978-1-4939-3623-6
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Manja Idorn
            affiliation:
                  name:Copenhagen University Hospital Herlev
                  address:
                     name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Per thor Straten
            affiliation:
                  name:Copenhagen University Hospital Herlev
                  address:
                     name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Inge Marie Svane
            affiliation:
                  name:Copenhagen University Hospital Herlev
                  address:
                     name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Copenhagen University Hospital Herlev
                  address:
                     name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Özcan Met
            affiliation:
                  name:Copenhagen University Hospital Herlev
                  address:
                     name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Copenhagen University Hospital Herlev
                  address:
                     name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Tumor-infiltrating lymphocytes (TILs), mRNA transfection, Cancer immunotherapy, Tumor homing, Chemokine receptor
      description:Adoptive T-cell therapy based on the infusion of patient’s own immune cells after ex vivo culturing is among the most potent forms of personalized treatment among recent clinical developments for the treatment of cancer. However, despite high rates of successful initial clinical responses, only about 20 % of patients with metastatic melanoma treated with tumor-infiltrating lymphocytes (TILs) enter complete and long-term regression, with the majority either relapsing after initial partial regression or not benefiting at all. Previous studies have shown a positive correlation between the number infused T cells migrating to the tumor and the clinical response, but also that only a small fraction of adoptively transferred T cells reach the tumor site. In this chapter, we describe a protocol for transfection of TILs with mRNA encoding the chemokine receptor CXCR2 transiently redirecting and improving TILs migration toward tumor-secreted chemokines in vitro.
      datePublished:2016
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Book:
      name:Synthetic mRNA
      isbn:
         978-1-4939-3625-0
         978-1-4939-3623-6
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Copenhagen University Hospital Herlev
      address:
         name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
         type:PostalAddress
      name:Copenhagen University Hospital Herlev
      address:
         name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
         type:PostalAddress
      name:Copenhagen University Hospital Herlev
      address:
         name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
         type:PostalAddress
      name:Copenhagen University Hospital Herlev
      address:
         name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
         type:PostalAddress
      name:Copenhagen University Hospital Herlev
      address:
         name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
         type:PostalAddress
      name:Copenhagen University Hospital Herlev
      address:
         name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
         type:PostalAddress
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Person:
      name:Manja Idorn
      affiliation:
            name:Copenhagen University Hospital Herlev
            address:
               name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Per thor Straten
      affiliation:
            name:Copenhagen University Hospital Herlev
            address:
               name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
               type:PostalAddress
            type:Organization
      name:Inge Marie Svane
      affiliation:
            name:Copenhagen University Hospital Herlev
            address:
               name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
               type:PostalAddress
            type:Organization
            name:Copenhagen University Hospital Herlev
            address:
               name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
               type:PostalAddress
            type:Organization
      name:Özcan Met
      affiliation:
            name:Copenhagen University Hospital Herlev
            address:
               name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
               type:PostalAddress
            type:Organization
            name:Copenhagen University Hospital Herlev
            address:
               name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
      name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
      name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
      name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
      name:Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark
      name:Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark
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