We are analyzing https://link.springer.com/chapter/10.1007/978-981-97-1666-1_8.

Title:
Autophagy Plays a Dual Role in Drug Resistance | SpringerLink
Description:
Autophagy is a crucial mechanism that maintains the balance of cellular homeostasis by removing faulty or unneeded proteins as well as damaged or aged organelles in cells. Autophagy is triggered by the formation of autophagosomes, which sequester and enclose...
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Schema {🗺️}

ScholarlyArticle:
      headline:Autophagy Plays a Dual Role in Drug Resistance
      pageEnd:267
      pageStart:243
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-97-1666-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Drug Resistance in Cancer: Mechanisms and Strategies
         isbn:
            978-981-97-1666-1
            978-981-97-1665-4
         type:Book
      publisher:
         name:Springer Nature Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Sameer Ullah Khan
            affiliation:
                  name:CSIR-Indian Institute of Integrative Medicine
                  address:
                     name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Division of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kaneez Fatima
            affiliation:
                  name:CSIR-Indian Institute of Integrative Medicine
                  address:
                     name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
                     type:PostalAddress
                  type:Organization
                  name:Academy of Scientific and Innovative Research (AcSIR)
                  address:
                     name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shariqa Jan
            affiliation:
                  name:CSIR-Indian Institute of Integrative Medicine
                  address:
                     name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
                     type:PostalAddress
                  type:Organization
                  name:Academy of Scientific and Innovative Research (AcSIR)
                  address:
                     name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Asif Ali
            affiliation:
                  name:School of Biomedical Sciences, Ulster University
                  address:
                     name:School of Biomedical Sciences, Ulster University, Coleraine, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abubakar Wani
            affiliation:
                  name:St. Jude Children’s Research Hospital
                  address:
                     name:St. Jude Children’s Research Hospital, Memphis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Baseerat Hamza
            affiliation:
                  name:Institute of Technology, University of Kashmir
                  address:
                     name:Department of Applied Sciences, Institute of Technology, University of Kashmir, Srinagar, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fayaz Malik
            affiliation:
                  name:CSIR-Indian Institute of Integrative Medicine
                  address:
                     name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
                     type:PostalAddress
                  type:Organization
                  name:Academy of Scientific and Innovative Research (AcSIR)
                  address:
                     name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Autophagy, Chemoresistance, Apoptosis, Cancer, Multidrug resistance
      description:Autophagy is a crucial mechanism that maintains the balance of cellular homeostasis by removing faulty or unneeded proteins as well as damaged or aged organelles in cells. Autophagy is triggered by the formation of autophagosomes, which sequester and enclose anomalous constituents. Subsequently, autophagosomes combine with lysosomes to efficiently recycle or eliminate degradative cargo. Autophagy regulation plays a dual role in both suppressing and promoting cancer in many types of malignancies in a context-dependent manner. In addition, autophagy regulates the characteristics of tumor formation, the spread of cancer, the occurrence of cancer stem cells, and the resistance to drugs used in cancer treatment. Autophagy regulators are employed to modify autophagy for the purpose of anticancer therapy. However, the dual functions of autophagy hinder their effectiveness in this therapy, thereby serving as the primary cause of treatment failure. The chapter provides a concise overview of the mechanisms behind autophagy and its correlation with carcinogenesis, metastasis, and resistance to anticancer drugs. Ultimately, we examine the potential and efficacy of addressing autophagy as a prospective therapeutic approach in anticancer treatment resistance.
      datePublished:2024
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Book:
      name:Drug Resistance in Cancer: Mechanisms and Strategies
      isbn:
         978-981-97-1666-1
         978-981-97-1665-4
Organization:
      name:Springer Nature Singapore
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         type:ImageObject
      name:CSIR-Indian Institute of Integrative Medicine
      address:
         name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Division of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:CSIR-Indian Institute of Integrative Medicine
      address:
         name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
         type:PostalAddress
      name:Academy of Scientific and Innovative Research (AcSIR)
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         name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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      name:CSIR-Indian Institute of Integrative Medicine
      address:
         name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
         type:PostalAddress
      name:Academy of Scientific and Innovative Research (AcSIR)
      address:
         name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
         type:PostalAddress
      name:School of Biomedical Sciences, Ulster University
      address:
         name:School of Biomedical Sciences, Ulster University, Coleraine, UK
         type:PostalAddress
      name:St. Jude Children’s Research Hospital
      address:
         name:St. Jude Children’s Research Hospital, Memphis, USA
         type:PostalAddress
      name:Institute of Technology, University of Kashmir
      address:
         name:Department of Applied Sciences, Institute of Technology, University of Kashmir, Srinagar, India
         type:PostalAddress
      name:CSIR-Indian Institute of Integrative Medicine
      address:
         name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
         type:PostalAddress
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Person:
      name:Sameer Ullah Khan
      affiliation:
            name:CSIR-Indian Institute of Integrative Medicine
            address:
               name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Division of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Kaneez Fatima
      affiliation:
            name:CSIR-Indian Institute of Integrative Medicine
            address:
               name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
               type:PostalAddress
            type:Organization
            name:Academy of Scientific and Innovative Research (AcSIR)
            address:
               name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
               type:PostalAddress
            type:Organization
      name:Shariqa Jan
      affiliation:
            name:CSIR-Indian Institute of Integrative Medicine
            address:
               name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
               type:PostalAddress
            type:Organization
            name:Academy of Scientific and Innovative Research (AcSIR)
            address:
               name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
               type:PostalAddress
            type:Organization
      name:Asif Ali
      affiliation:
            name:School of Biomedical Sciences, Ulster University
            address:
               name:School of Biomedical Sciences, Ulster University, Coleraine, UK
               type:PostalAddress
            type:Organization
      name:Abubakar Wani
      affiliation:
            name:St. Jude Children’s Research Hospital
            address:
               name:St. Jude Children’s Research Hospital, Memphis, USA
               type:PostalAddress
            type:Organization
      name:Baseerat Hamza
      affiliation:
            name:Institute of Technology, University of Kashmir
            address:
               name:Department of Applied Sciences, Institute of Technology, University of Kashmir, Srinagar, India
               type:PostalAddress
            type:Organization
      name:Fayaz Malik
      affiliation:
            name:CSIR-Indian Institute of Integrative Medicine
            address:
               name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
               type:PostalAddress
            type:Organization
            name:Academy of Scientific and Innovative Research (AcSIR)
            address:
               name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
               type:PostalAddress
            type:Organization
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      name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
      name:Division of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
      name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
      name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
      name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
      name:School of Biomedical Sciences, Ulster University, Coleraine, UK
      name:St. Jude Children’s Research Hospital, Memphis, USA
      name:Department of Applied Sciences, Institute of Technology, University of Kashmir, Srinagar, India
      name:Division of Cancer Pharmacology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India
      name:Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
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