We are analyzing https://link.springer.com/chapter/10.1007/978-981-15-1580-4_8.

Title:
Siglecs at the Host–Pathogen Interface | SpringerLink
Description:
Siglecs are sialic acid (Sia) recognizing immunoglobulin-like receptors expressed on the surface of all the major leukocyte lineages in mammals. Siglecs recognize ubiquitous Sia epitopes on various glycoconjugates in the cell glycocalyx and transduce signals to...
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Keywords {🔍}

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Topics {✒️}

n-terminal v-set domain host anti-α-gal antibodies immune-based anti-infective strategies human anti-alpha-galactosyl antibodies triggering mdc-mediated trans-infection cell-mediated anti-viral responses open access chapter van den berg elicit anti-gq1b antibodies glycans-mediated host–pathogen interactions ligand-binding v-set domain siglec-1-expressing sinus-lining macrophages alpha-n-acetylneuraminic acid] gd1a/gm1a mimic induced pro-inflammatory cytokine il-6 exposed α-galactosyl epitopes n-terminal immunoglobulin domain sialic acid o-acetylation sialic acid-dependent manner siglec-e-deficient mice sialic acid-binding activity dendritic cell-mediated capture hiv-1-induced cytopathic effects nf-κb-dependent mechanisms suppressing anti-viral immunity sialic acid–binding immunoglobulin sialic acid-binding immunoglobulin cd169-mediated trans-infection high-dose lethal challenge campylobacter jejuni lipo-oligosaccharides pi3k/akt signaling pathways siglec v-set domain sialic acid-binding ig bone-marrow-derived macrophages anti-recognition phenomena ranging yung-chi chang mediating microbe–host interactions potentiate mdc-dependent capture mediates hiv-1 trans-infection β protein-expressing gbs th2-dominant cytokine responses sia-siglec-mediated interactions platelet-mediated antimicrobial killing surface-anchored β protein immunoreceptor-based activation motif human-specific siglec-11 shows called miller-fisher variant macrophage-specific receptor sialoadhesin siglec-1-mediated viral spreading immunoreceptor-based inhibition motif

Schema {🗺️}

ScholarlyArticle:
      headline:Siglecs at the Host–Pathogen Interface
      pageEnd:214
      pageStart:197
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-15-1580-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Lectin in Host Defense Against Microbial Infections
         isbn:
            978-981-15-1580-4
            978-981-15-1579-8
         type:Book
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yung-Chi Chang
            affiliation:
                  name:National Taiwan University
                  address:
                     name:Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Victor Nizet
            affiliation:
                  name:UC San Diego
                  address:
                     name:Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Sialic acid, Streptococcus, Pattern-recognition receptor, Trans-infection
      description:Siglecs are sialic acid (Sia) recognizing immunoglobulin-like receptors expressed on the surface of all the major leukocyte lineages in mammals. Siglecs recognize ubiquitous Sia epitopes on various glycoconjugates in the cell glycocalyx and transduce signals to regulate immunological and inflammatory activities of these cells. The subset known as CD33-related Siglecs is principally inhibitory receptors that suppress leukocyte activation, and recent research has shown that a number of bacterial pathogens use Sia mimicry to engage these Siglecs as an immune evasion strategy. Conversely, Siglec-1 is a macrophage phagocytic receptor that engages GBS and other sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response, whereas certain viruses and parasites use Siglec-1 to gain entry to immune cells as a proximal step in the infectious process. Siglecs are positioned in crosstalk with other host innate immune sensing pathways to modulate the immune response to infection in complex ways. This chapter summarizes the current understanding of Siglecs at the host–pathogen interface, a field of study expanding in breadth and medical importance, and which provides potential targets for immune-based anti-infective strategies.
      datePublished:2020
      isAccessibleForFree:1
      context:https://schema.org
Book:
      name:Lectin in Host Defense Against Microbial Infections
      isbn:
         978-981-15-1580-4
         978-981-15-1579-8
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Taiwan University
      address:
         name:Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
         type:PostalAddress
      name:UC San Diego
      address:
         name:Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yung-Chi Chang
      affiliation:
            name:National Taiwan University
            address:
               name:Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Victor Nizet
      affiliation:
            name:UC San Diego
            address:
               name:Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
      name:Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, and Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, USA

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