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Flaviviral RNA Structures and Their Role in Replication and Immunity | SpringerLink
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More than simple vectors of genetic information, flaviviral RNAs have emerged as critical regulators of the virus life cycle. Viral RNAs regulate interactions with viral and cellular proteins in both, mosquito and mammalian hosts to ultimately influence processes as...
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ScholarlyArticle:
headline:Flaviviral RNA Structures and Their Role in Replication and Immunity
pageEnd:62
pageStart:45
image:https://media.springernature.com/w153/springer-static/cover/book/978-981-10-8727-1.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Dengue and Zika: Control and Antiviral Treatment Strategies
isbn:
978-981-10-8727-1
978-981-10-8726-4
type:Book
publisher:
name:Springer Singapore
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Katell Bidet
affiliation:
name:Infectious Diseases IRG, Singapore-MIT Alliance for Research and Technology
address:
name:Infectious Diseases IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore
type:PostalAddress
type:Organization
type:Person
name:Mariano A. Garcia-Blanco
affiliation:
name:Duke-NUS Medical School
address:
name:Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
type:PostalAddress
type:Organization
name:University of Texas Medical Branch
address:
name:Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, USA
type:PostalAddress
type:Organization
type:Person
keywords:Flavivirus, RNA, Structures, Replication, Pathogenesis
description:More than simple vectors of genetic information, flaviviral RNAs have emerged as critical regulators of the virus life cycle. Viral RNAs regulate interactions with viral and cellular proteins in both, mosquito and mammalian hosts to ultimately influence processes as diverse as RNA replication, translation, packaging or pathogenicity. In this chapter, we will review the current knowledge of the role of sequence and structures in the flaviviral RNA in viral propagation and interaction with the host cell. We will also cover the increasing body of evidence linking viral non-coding RNAs with pathogenicity, host immunity and epidemic potential.
datePublished:2018
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