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Title:
Structural Biology of the Membrane Attack Complex | SpringerLink
Description:
The complement system is an intricate network of serum proteins that mediates humoral innate immunity through an amplification cascade that ultimately leads to recruitment of inflammatory cells or opsonisation or killing of pathogens. One effector arm of this network...
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Topics {✒️}

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Questions {❓}

Bamford DH, Grimes JM, Stuart DI (2005) What does structure tell us about virus evolution?
Markiewski MM, Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD (2007) Complement and coagulation: strangers or partners in crime?
Nabholz M, Tschopp J (1989) CTL-mediated cytolysis: perforin and alternative pathways?

Schema {🗺️}

ScholarlyArticle:
      headline:Structural Biology of the Membrane Attack Complex
      pageEnd:116
      pageStart:83
      image:https://media.springernature.com/w153/springer-static/cover/book/978-94-017-8881-6.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
         isbn:
            978-94-017-8881-6
            978-94-017-8880-9
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Andreas F.-P. Sonnen
            affiliation:
                  name:University Medical Center Freiburg
                  address:
                     name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Philipp Henneke
            affiliation:
                  name:University Medical Center Freiburg
                  address:
                     name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Complememt system, Lipid membrane pore, Membrane attack complex, Pore-forming proteins, Structural biology
      description:The complement system is an intricate network of serum proteins that mediates humoral innate immunity through an amplification cascade that ultimately leads to recruitment of inflammatory cells or opsonisation or killing of pathogens. One effector arm of this network is the terminal pathway of complement, which leads to the formation of the membrane attack complex (MAC) composed of complement components C5b, C6, C7, C8 and C9. Upon formation of C5 convertases via the classical or alternative pathways of complement activation, C5b is generated from C5 by proteolytic cleavage, nucleating a series of association and polymerisation reactions of the MAC-constituting complement components that culminate in pore formation of pathogenic membranes. Recent structures of MAC components and homologous proteins significantly increased our understanding of oligomerisation, membrane association and integration, shedding light onto the molecular mechanism of this important branch of the innate immune system.
      datePublished:2014
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Book:
      name:MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
      isbn:
         978-94-017-8881-6
         978-94-017-8880-9
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University Medical Center Freiburg
      address:
         name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University Medical Center Freiburg
      address:
         name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Andreas F.-P. Sonnen
      affiliation:
            name:University Medical Center Freiburg
            address:
               name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Philipp Henneke
      affiliation:
            name:University Medical Center Freiburg
            address:
               name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
      name:Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
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