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Title:
Intracellular Calcium Homeostasis and Signaling | SpringerLink
Description:
Ca2+ is a universal carrier of biological information: it controls cell life from its origin at fertilization to its end in the process of programmed cell death. Ca2+ is a conventional diffusible second messenger released inside cells by the interaction of first...
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Schema {🗺️}

ScholarlyArticle:
      headline:Intracellular Calcium Homeostasis and Signaling
      pageEnd:168
      pageStart:119
      image:https://media.springernature.com/w153/springer-static/cover/book/978-94-007-5561-1.jpg
      genre:
         Chemistry and Materials Science
         Chemistry and Material Science (R0)
      isPartOf:
         name:Metallomics and the Cell
         isbn:
            978-94-007-5561-1
            978-94-007-5560-4
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Marisa Brini
            affiliation:
                  name:University of Padova
                  address:
                     name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Tito Calì
            affiliation:
                  name:University of Padova
                  address:
                     name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Denis Ottolini
            affiliation:
                  name:University of Padova
                  address:
                     name:Department of Biomedical Sciences, University of Padova, Padova, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ernesto Carafoli
            affiliation:
                  name:Venetian Institute of Molecular Medicine (VIMM)
                  address:
                     name:Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:apoptosis, calcium, calcium buffering proteins, calcium sensor proteins, calmodulin, fertilization, gene expression, ion pumps, mitochondria, protein dephosphorylation, protein phosphorylation, Please cite as: Met. Ions Life Sci. 12 (2013) 119–168
      description:Ca2+ is a universal carrier of biological information: it controls cell life from its origin at fertilization to its end in the process of programmed cell death. Ca2+ is a conventional diffusible second messenger released inside cells by the interaction of first messengers with plasma membrane receptors. However, it can also penetrate directly into cells to deliver information without the intermediation of first or second messengers. Even more distinctively, Ca2+ can act as a first messenger, by interacting with a plasma membrane receptor to set in motion intracellular signaling pathways that involve Ca2+ itself. Perhaps the most distinctive property of the Ca2+ signal is its ambivalence: while essential to the correct functioning of cells, Ca2+ becomes an agent that mediates cell distress, or even (toxic) cell death, if its concentration and movements inside cells are not carefully tuned. Ca2+ is controlled by reversible complexation to specific proteins, which could be pure Ca2+ buffers, or which, in addition to buffering Ca2+, also decode its signal to pass it on to targets. The most important actors in the buffering of cell Ca2+ are proteins that transport it across the plasma membrane and the membrane of the organelles: some have high Ca2+ affinity and low transport capacity (e.g., Ca2+ pumps), others have opposite properties (e.g., the Ca2+ uptake system of mitochondria). Between the initial event of fertilization, and the terminal event of programmed cell death, the Ca2+ signal regulates the most important activities of the cell, from the expression of genes, to heart and muscle contraction and other motility processes, to diverse metabolic pathways involved in the generation of cell fuels.
      datePublished:2013
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Book:
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      isbn:
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         978-94-007-5560-4
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      name:Springer Netherlands
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      name:University of Padova
      address:
         name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
         type:PostalAddress
      name:University of Padova
      address:
         name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
         type:PostalAddress
      name:University of Padova
      address:
         name:Department of Biomedical Sciences, University of Padova, Padova, Italy
         type:PostalAddress
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            name:University of Padova
            address:
               name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Tito Calì
      affiliation:
            name:University of Padova
            address:
               name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
               type:PostalAddress
            type:Organization
      name:Denis Ottolini
      affiliation:
            name:University of Padova
            address:
               name:Department of Biomedical Sciences, University of Padova, Padova, Italy
               type:PostalAddress
            type:Organization
      name:Ernesto Carafoli
      affiliation:
            name:Venetian Institute of Molecular Medicine (VIMM)
            address:
               name:Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
      name:Department of Comparative Biomedicine and Food Sciences, University of Padova, Padova, Italy
      name:Department of Biomedical Sciences, University of Padova, Padova, Italy
      name:Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
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