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Title:
The Rediscovery of DON (6-Diazo-5-oxo-L-norleucine) | SpringerLink
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DON (6-diazo-5-oxo-l-norleucine) and azotomycin are glutamine antagonists that were tested in human malignancies in the 1950s. Azotomycin demonstrated significant activity in colorectal cancer. DON is probably the active form of azotomycin. Recent impressive results...
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cancer, google, scholar, don, pubmed, cas, article, chapter, azotomycin, privacy, cookies, content, publish, research, diazooxolnorleucine, muggia, human, clinical, chemotherapy, data, information, search, results, tumor, preview, access, york, study, log, journal, chemo, immunopharmacology, catane, recent, glutamine, activity, colorectal, phase, download, vivo, res, cooney, disease, chemother, rep, berlin, heidelberg, springer, optional, personal,
Topics {βοΈ}
6-dia- zo-5-oxo-l-norleucine 6-diazo-5-oxo-l-norleucine privacy choices/manage cookies neoplastic mouse tissues cx-2 colon tumor download preview pdf l-asparaginase synthetase hΓ΄pital paul-brousse human tumor xenografts chapter cancer chemo colorectal cancer cells cancer chemotherapy ii european economic area long-lasting reduction triazine mimic antibiotics dna-binding implications hollow fiber assay von hoff dd davis hl jr med clin north initial therapeutic observations 10th international congress journal finder publish spheroids article 02 conditions privacy policy human neoplastic disease phase ii study assoc cancer res previous clinical data accepting optional cookies book series 5-fluorouracil-doxorubicin combination ovejera aa cancer research main content log impressive activity rosenbluth rj cancer chemo clinical study recent impressive results check access ethics access comparative effect bronchogenic carcinoma permissions reprints colorectal cancer heidelberg journal publish personal data privacy policy
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ScholarlyArticle:
headline:The Rediscovery of DON (6-Diazo-5-oxo-L-norleucine)
pageEnd:263
pageStart:258
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-81488-4.jpg
genre:
Medicine
Medicine (R0)
isPartOf:
name:Cancer Chemo- and Immunopharmacology
isbn:
978-3-642-81488-4
978-3-642-81490-7
type:Book
publisher:
name:Springer Berlin Heidelberg
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:D. L. Kisner
affiliation:
type:Person
name:R. Catane
affiliation:
type:Person
name:F. M. Muggia
affiliation:
type:Person
keywords:Human Tumor Xenograft, Orotic Acid, Carbamyl Phosphate, Daily Dose Schedule, Carbamyl Phosphate Synthetase
description:DON (6-diazo-5-oxo-l-norleucine) and azotomycin are glutamine antagonists that were tested in human malignancies in the 1950s. Azotomycin demonstrated significant activity in colorectal cancer. DON is probably the active form of azotomycin. Recent impressive results for both of these agents in human tumor xenografts (especially the CX-2 colon tumor) have stimulated renewed clinical interest in DON, the more readily available agent. DON mechanism of action, clinical pharmacology, previous clinical data, and current phase I studies are discussed.
datePublished:1980
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978-3-642-81488-4
978-3-642-81490-7
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name:D. L. Kisner
affiliation:
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affiliation:
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affiliation:
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