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Title:
Growth of Human Tumors in Immune-Deficient scid Mice and nude Mice | SpringerLink
Description:
The ability to grow human tumors in immune-deficient mice offers offers many research opportunities (Sharkey and Fogh 1984). In addition to simply providing a source of cells for investigation, such animals can provide models for testing therapeutic protocols...
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Keywords {π}
mice, human, google, scholar, nude, scid, cancer, tumors, growth, phillips, article, research, jewett, gallie, toronto, privacy, cookies, content, information, publish, mouse, paper, bosma, access, download, chapter, canada, search, immunology, fogh, tumor, preview, springer, personal, data, log, journal, conference, immunedeficient, book, grow, metastasis, severe, open, cell, nature, breast, res, usa, division,
Topics {βοΈ}
month download article/chapter pdx-bearing humanized mice immune-deficient scid mice privacy choices/manage cookies device instant download severe combined immunodeficiency european economic area testing therapeutic protocols journal finder publish conditions privacy policy enucleation induced metastasis download preview pdf grow human tumors accepting optional cookies athymic βnudeβ mouse check access ethics access conference paper main content log paper cite book series chapter usdΒ 29 cancer research scid mice tumor induction permissions reprints cell biochem 35 human tumors scid mouse heidelberg journal publish cancer res 47 immune deficiency privacy policy research opportunities chapter log affiliations division books a nude mice bosma mj bosma division gallie bl optional cookies personal data manage preferences hematology/oncology paper phillips tumour growth growth regulation data protection
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ScholarlyArticle:
headline:Growth of Human Tumors in Immune-Deficient scid Mice and nude Mice
pageEnd:263
pageStart:259
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-74974-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:The Scid Mouse
isbn:
978-3-642-74974-2
978-3-642-74976-6
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publisher:
name:Springer Berlin Heidelberg
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type:ImageObject
type:Organization
author:
name:R. A. Phillips
affiliation:
name:The Hospital for Sick Children
address:
name:Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Department of Medical Genetics, University of Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:M. A. S. Jewett
affiliation:
name:The Hospital for Sick Children
address:
name:Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Department of Medical Genetics, University of Toronto, Canada
type:PostalAddress
type:Organization
name:The Wellesley Hospital
address:
name:Division of Urology, The Wellesley Hospital, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Department of Surgery, University of Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:B. L. Gallie
affiliation:
name:The Hospital for Sick Children
address:
name:Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Department of Medical Genetics, University of Toronto, Canada
type:PostalAddress
type:Organization
type:Person
keywords:Nude Mouse, Human Tumor, Scid Mouse, Severe Combine Immunodeficiency, Human Lung Tumor
description:The ability to grow human tumors in immune-deficient mice offers offers many research opportunities (Sharkey and Fogh 1984). In addition to simply providing a source of cells for investigation, such animals can provide models for testing therapeutic protocols (Niederkorn 1984; Brunner et al. 1987), for studying metastasis (Dore et al. 1987), and for analyzing changes associated with tumor induction and progression (Sordat and Wang 1984). Although nude mice have been used for many years to grow various human tumors, we expected that scid mice might be better recipients for growth of human tumors because the immune deficiency in scid mice is more severe than that in nude mice (Bosma et al. 1983). To test this hypothesis, we have compared the ability of various different human tumors to grow subcutaneously in nude mice and scid mice.
datePublished:1989
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978-3-642-74976-6
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name:Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada
type:PostalAddress
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name:University of Toronto
address:
name:Department of Medical Genetics, University of Toronto, Canada
type:PostalAddress
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name:M. A. S. Jewett
affiliation:
name:The Hospital for Sick Children
address:
name:Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
name:University of Toronto
address:
name:Department of Medical Genetics, University of Toronto, Canada
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name:Department of Medical Genetics, University of Toronto, Canada
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name:Department of Medical Genetics, University of Toronto, Canada
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