We are analyzing https://link.springer.com/chapter/10.1007/978-3-642-49295-2_8.

Title:
The Transforming Growth Factor-βs | SpringerLink
Description:
Following the initial purification and characterization of transforming growth factor-β (TGF-β) as a homodimeric, 25-kDa peptide (Frolik et al. 1983; Assoian et al. 1983; Roberts et al. 1983 a), there has been an exponential increase in knowledge relating...
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Keywords {🔍}

growth, google, scholar, pubmed, cas, transforming, article, cell, factor, factorβ, sporn, biol, cells, roberts, human, type, chem, res, tgfβ, proc, usa, factorbeta, natl, acad, sci, factors, beta, expression, rat, biochem, biophys, moses, regulation, cancer, fibroblasts, commun, inhibitor, gene, wakefield, massagué, differentiation, mrna, receptors, nature, mol, receptor, inhibition, smith, proliferation, flanders,

Topics {✒️}

platelet-derived growth factor transforming growth factor-beta transforming growth-factor beta transforming growth factor-β transforming growth factor-β β-transforming growth factor transforming growth factor-βl transforming growth factor-fl transforming growth factor-β1 transforming growth factor-β2 transforming grwoth factor-β follicle-stimulating hormone-induced differentiation transforming growth factor-βs epstein-barr virus mediates heparin-binding growth factors tgf-β induced mitogenesis bone-derived cell line tgf-β inhibits proliferation lymphokine-activated killer cells insulin-resistant diabetes due leydig cell steroidogenesis transforming growth factor transforming growth factor-/3 transforming growth factor c-myc proto-oncogene expression growth-related gene expression high-affinity receptor van obberghen-schilling steady-state amounts high affinity receptors epidermal growth factor sarcoma growth factor recombinant tgf-βl distinct bone-inducing factors fibroblast growth factor growth factor related transforming growth factors transforming growth factorbeta bovine follicular fluid growth factor production collagen mrna levels tgf-beta gene osteoblast-enriched cell cultures porcine tgf-β cartilage-inducing factor cartilage-inducing factor human glioblastoma-derived regulate gene expression fetal rat bone type iii collagen

Questions {❓}

Ernst M, Schmid C, Frandenfelt C, Froesch ER (1988) Estradiol stimulation of osteoblast proliferation in vitro: mediator roles for TGF-β, PE2, insulin-like growth factor (IGF)?
Haddow A (1972) Molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing?

Schema {🗺️}

ScholarlyArticle:
      headline:The Transforming Growth Factor-βs
      pageEnd:472
      pageStart:419
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-49295-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Peptide Growth Factors and Their Receptors I
         isbn:
            978-3-642-49295-2
            978-3-642-49297-6
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:A. B. Roberts
            affiliation:
            type:Person
            name:M. B. Sporn
            affiliation:
            type:Person
      keywords:Transform Growth Factor, Granulosa Cell, Leydig Cell Steroidogenesis, Porcine Platelet, Chick Embryo Chondrocytes
      description:Following the initial purification and characterization of transforming growth factor-β (TGF-β) as a homodimeric, 25-kDa peptide (Frolik et al. 1983; Assoian et al. 1983; Roberts et al. 1983 a), there has been an exponential increase in knowledge relating to this molecule. The cloning of TGF-βl and the resultant elucidation of its precursor structure (Derynck et al. 1985) have led to the identification of at least four other forms of TGF-β and the definition of a larger gene family comprising many other structurally related, but functionally distinct, regulatory proteins. The original narrow definition of TGF-β,in terms of induction of a transformed phenotype in mesenchymal cells (Moses et al. 1981; Roberts et al. 1981, 1983 b), has now been supplanted by the knowledge that this peptide affects many functions in nearly all cells. Immunohistochemical and in situ hybridization studies have identified in vivo sites of TGF-β action; its broad spectrum of cellular targets as well as its multifunctional actions suggest that it has a pivotal control function in many physiological and pathological processes. Elucidation of physiological mechanisms of activation of the latent forms of the TGF-βs and of regulation of expression of the TGF-βs and their receptors are important problems that must still be solved for better understanding of the action of the TGF-βs. In this chapter we summarize current knowledge of the chemistry and complex biology of the growing family of TGF-βs.
      datePublished:1990
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Book:
      name:Peptide Growth Factors and Their Receptors I
      isbn:
         978-3-642-49295-2
         978-3-642-49297-6
Organization:
      name:Springer Berlin Heidelberg
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