We are analyzing https://link.springer.com/chapter/10.1007/978-3-642-28160-0_9.

Title:
Emerging Technologies for CTC Detection Based on Depletion of Normal Cells | SpringerLink
Description:
Properly conducted, an enrichment step can improve selectivity, sensitivity, yield, and most importantly, significantly reduce the time needed to isolate rare circulating tumor cells (CTCs). The enrichment process can be broadly categorized as positive selection...
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Keywords {🔍}

google, scholar, cancer, cells, pubmed, cas, article, breast, cell, circulating, tumor, blood, res, patients, detection, enrichment, clin, chapter, zborowski, transition, human, chalmers, magnetic, neck, epithelial, mesenchymal, depletion, rare, carcinoma, head, stem, negative, immunomagnetic, separation, flow, pantel, quadrupole, tumour, peripheral, metastatic, epithelialmesenchymal, privacy, cookies, content, information, publish, research, search, residual, disease,

Topics {✒️}

human colon-cancer-initiating cells month download article/chapter human breast cancer–observations cell search system epithelial-mesenchymal transition markers minimal residual disease magnetophoretic cell sorting device instant download privacy choices/manage cookies immunomagnetic cell enrichment negative selection method disseminated tumor cells human breast cancer quadrupole magnetic field antibody binding capacity positive selection methodology editor information editors magnetic cell separation stem cell markers breast tumor cells rare-cell detector disseminating tumour cells circulating epithelial cells epithelial mesenchymal transition epithelial-mesenchymal transition ehrlich ascites tumour cytokeratin-positive cells cell tracking velocimetry metastatic breast cancer iii breast cancer breast cancer relates circulating tumor cells mesenchymal tumor cells squamous cell carcinoma ohio state university immunomagnetic cell separation rare cancer cells immune-induced epithelial high speed detection rare cell isolation tumor-antigen heterogeneity hematopoietic progenitor cells specific biological properties k-ras genes miltenyi biotec gmbh pulse-injection studies magnetically induced motion superparamagnetic microparticles detected institut jules bordet normal cells chapter

Schema {🗺️}

ScholarlyArticle:
      headline:Emerging Technologies for CTC Detection Based on Depletion of Normal Cells
      pageEnd:110
      pageStart:97
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-28160-0.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer
         isbn:
            978-3-642-28160-0
            978-3-642-28159-4
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Maryam Lustberg
            affiliation:
                  name:The Ohio State University
                  address:
                     name:Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kris R. Jatana
            affiliation:
                  name:The Ohio State University and Nationwide Children’s Hospital
                  address:
                     name:Department of Otolaryngology—Head and Neck Surgery, The Ohio State University and Nationwide Children’s Hospital, Columbus, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maciej Zborowski
            affiliation:
                  name:Cleveland Clinic
                  address:
                     name:Department of Biomedical Engineering, Cleveland Clinic, Cleveland, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeffrey J. Chalmers
            affiliation:
                  name:The Ohio State University
                  address:
                     name:Professor William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Triple Negative Breast Cancer, Disseminate Tumor Cell, CellSearch System, Cytokeratin Positive Cell, Metastatic Triple Negative Breast Cancer
      description:Properly conducted, an enrichment step can improve selectivity, sensitivity, yield, and most importantly, significantly reduce the time needed to isolate rare circulating tumor cells (CTCs). The enrichment process can be broadly categorized as positive selection versus negative depletion, or in some cases, a combination of both. We have developed a negative depletion CTC enrichment strategy that relies on the removal of normal cells using immunomagnetic separation in the blood of cancer patients. This method is based on the combination of magnetic and fluid forces in an axial, laminar flow in long cylinders placed in quadrupole magnets. Using this technology, we have successfully isolated CTCs from patients with breast carcinoma and squamous cell carcinoma of the head and neck. In contrast to a positive selection methodology, this approach provides an unbiased characterization of these cells, including markers associated with epithelial mesenchymal transition.
      datePublished:2012
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Book:
      name:Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer
      isbn:
         978-3-642-28160-0
         978-3-642-28159-4
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Ohio State University
      address:
         name:Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, USA
         type:PostalAddress
      name:The Ohio State University and Nationwide Children’s Hospital
      address:
         name:Department of Otolaryngology—Head and Neck Surgery, The Ohio State University and Nationwide Children’s Hospital, Columbus, USA
         type:PostalAddress
      name:Cleveland Clinic
      address:
         name:Department of Biomedical Engineering, Cleveland Clinic, Cleveland, USA
         type:PostalAddress
      name:The Ohio State University
      address:
         name:Professor William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Maryam Lustberg
      affiliation:
            name:The Ohio State University
            address:
               name:Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, USA
               type:PostalAddress
            type:Organization
      name:Kris R. Jatana
      affiliation:
            name:The Ohio State University and Nationwide Children’s Hospital
            address:
               name:Department of Otolaryngology—Head and Neck Surgery, The Ohio State University and Nationwide Children’s Hospital, Columbus, USA
               type:PostalAddress
            type:Organization
      name:Maciej Zborowski
      affiliation:
            name:Cleveland Clinic
            address:
               name:Department of Biomedical Engineering, Cleveland Clinic, Cleveland, USA
               type:PostalAddress
            type:Organization
      name:Jeffrey J. Chalmers
      affiliation:
            name:The Ohio State University
            address:
               name:Professor William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Internal Medicine, Division of Medical Oncology, The Ohio State University, Columbus, USA
      name:Department of Otolaryngology—Head and Neck Surgery, The Ohio State University and Nationwide Children’s Hospital, Columbus, USA
      name:Department of Biomedical Engineering, Cleveland Clinic, Cleveland, USA
      name:Professor William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, USA
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