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Toll-Like Receptors (TLRs) and Their Ligands | SpringerLink
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The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize microbial components that are essential for the survival of the...
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google, scholar, cas, pubmed, tolllike, receptor, immunol, drosophila, akira, immune, recognition, innate, tlr, immunity, receptors, response, signaling, nature, nat, responses, med, biol, role, malaria, activation, infection, protein, hoffmann, cell, takeuchi, takeda, toll, cells, science, tlrs, exp, infect, host, defense, hemmi, virus, gene, chapter, bacteria, proc, natl, acad, sci, usa, cruzi,
Topics {βοΈ}
herpes simplex virus-2 ubiquitin-proteasome pathway represses pgrp-lc act synergistically ifn-gamma-primed macrophages syk-dependent cytokine induction murine retroviruses activate double-stranded rna reveals cell-mediated immune responses kurt-jones ea innate anti-fungal immunity jnk-mediated immune response receptor signalling path-ways control dorsoventral patterning activates nk cells cytokine production triggered major beta-glucan receptor species-specific recognition respiratory syncytial virus privacy choices/manage cookies innate antiviral responses activates antibacterial defense innate immune responses toll-mediated antifungal defense plasmacytoid dendritic cells double-stranded rna single-stranded rna reactive oxygen production lipopolysaccharide-signaling complex drosophila immune deficiency gram-positive bacteria van der graaf humoral immune responses life sciences biomedical antibacterial immune responses innate immune response interferon-alpha protein relish regulates innate immune defense pattern recognition pathway innate immune recognition sp Γ€tzle de arruda lb trypanosoma cruzi glycoinositolphospholipids mediating immune response bacterial flagellin innate immune system human cerebral malaria mouse cytomegalovirus infection distinct antipathogen responses drosophila immune response
Questions {β}
- Netea MG, van Deuren M, Kullberg BJ, Cavaillon JM, Van der Meer JW (2002b) Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?
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ScholarlyArticle:
headline:Toll-Like Receptors (TLRs) and Their Ligands
pageEnd:20
pageStart:1
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-540-72167-3.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Toll-Like Receptors (TLRs) and Innate Immunity
isbn:
978-3-540-72167-3
978-3-540-72166-6
type:Book
publisher:
name:Springer Berlin Heidelberg
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Satoshi Uematsu
affiliation:
type:Person
name:Shizuo Akira
affiliation:
name:Osaka University
address:
name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
type:PostalAddress
type:Organization
type:Person
keywords:Respiratory Syncytial Virus, West Nile Virus, Cerebral Malaria, Trypanosoma Cruzi, Toll Pathway
description:The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize microbial components that are essential for the survival of the microorganism. PRRs are germline-encoded, nonclonal, and expressed constitutively in the host. Different PRRs react with specific ligands and lead to distinct antipathogen responses. Among them, Toll-like receptors (TLRs) are capable of sensing organisms ranging from bacteria to fungi, protozoa, and viruses, and they play a major role in innate immunity. Here, we review the mechanism of pathogen recognition by TLRs.
datePublished:2008
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isbn:
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name:Springer Berlin Heidelberg
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name:Osaka University
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name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
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name:Satoshi Uematsu
affiliation:
name:Shizuo Akira
affiliation:
name:Osaka University
address:
name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
type:PostalAddress
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name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
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