We are analyzing https://link.springer.com/chapter/10.1007/978-3-540-68976-8_12.

Title:
The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles | SpringerLink
Description:
Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to tumors and contribute to the formation of tumor-associated stroma. The biological rationale for tumor recruitment of MSC remains unclear but may represent an effort of the host to...
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

google, scholar, pubmed, cas, cells, stem, mesenchymal, cancer, cell, tumor, human, bone, stromal, marrow, res, growth, marrowderived, stroma, transplantation, blood, fibroblasts, chapter, adult, int, gene, mol, model, mammary, tissue, delivery, potential, vivo, breast, vehicles, marini, msc, tumorassociated, microenvironment, mice, med, epithelial, myofibroblasts, factor, progenitors, experimental, tumors, therapeutic, access, plasticity, therapy,

Topics {✒️}

bone-marrow-derived myofibroblasts contribute bone marrow-derived progenitors bone marrow-derived cells growth factor-mediated interaction stromal-derived factor-1 regulate bone-marrow-derived myofibroblasts bone-marrow-transplanted mice month download article/chapter transforming growth factor-beta1 elevated sdf-1/cxcl12 secretion kleijburg-van der keur human bone marrow cancer-induced stromal reaction kunz-schughart la marrow stromal cells mesenchymal stem cells bone marrow contribution cerebral ischemia model human stem cells bone marrow stroma targeted-gene delivery vehicles hepatocyte growth factor bone marrow origin hematopoietic stem cells human factor ix human rhabdomyosarcoma cells de la fuente renewing stem cells culture unravels diversity contribute oncogenic signals human growth hormone privacy choices/manage cookies tumor stem cells umbilical cord blood adult unconditioned mice normal stromal cells epithelial progenitor cells stem cell proteomes epithelial mesenchymal transitions produce high concentrations reduce infarct size spinal cord injuries de lera tl mouse mammary gland device instant download invasive ductal carcinoma mesenchymal-epithelial interactions editor information editors unirradiated epithelial cells active stromal participants

Questions {❓}

Bissell MJ, Labarge MA (2005) Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?
Harrington K, Alvarez-Vallina L, Crittenden M, et al (2002) Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?
Kunz-Schughart LA, Knuechel R (2002a) Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression?
Rowley DR (1998) What might a stromal response mean to prostate cancer progression?

Schema {🗺️}

ScholarlyArticle:
      headline:The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles
      pageEnd:283
      pageStart:263
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-540-68976-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Bone Marrow-Derived Progenitors
         isbn:
            978-3-540-68976-8
            978-3-540-68975-1
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:B. Hall
            affiliation:
                  name:Columbus Children’s Research Institute
                  address:
                     name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Andreeff
            affiliation:
                  name:The University of Texas M. D. Anderson Cancer Center
                  address:
                     name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:F. Marini
            affiliation:
                  name:The University of Texas M. D. Anderson Cancer Center
                  address:
                     name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Mesenchymal Stem Cell (MSC), Tumor Microenvironment, Tumor-associated Fibroblast (TAF), Stromagenesis, Myofibroblast, Desmoplasia, Tumor Stroma
      description:Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to tumors and contribute to the formation of tumor-associated stroma. The biological rationale for tumor recruitment of MSC remains unclear but may represent an effort of the host to blunt tumor cell growth and improve survival. There is mounting experimental evidence that normal stromal cells can revert malignant cell behavior, and separate studies have demonstrated that stromal cells can enhance tumor progression after acquisition of tumor-like genetic lesions. Together, these observations support the rationale for modifying normal MSC to deliver therapeutic proteins directly into the tumor microenvironment. Modified MSC can produce high concentrations of antitumor proteins directly within the Tumor mass, which have been shown to blunt tumor growth kinetics in experimental animal model systems. In this chapter we will address the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.
      datePublished:2007
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Bone Marrow-Derived Progenitors
      isbn:
         978-3-540-68976-8
         978-3-540-68975-1
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Columbus Children’s Research Institute
      address:
         name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
         type:PostalAddress
      name:The University of Texas M. D. Anderson Cancer Center
      address:
         name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas M. D. Anderson Cancer Center
      address:
         name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:B. Hall
      affiliation:
            name:Columbus Children’s Research Institute
            address:
               name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
               type:PostalAddress
            type:Organization
      name:M. Andreeff
      affiliation:
            name:The University of Texas M. D. Anderson Cancer Center
            address:
               name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:F. Marini
      affiliation:
            name:The University of Texas M. D. Anderson Cancer Center
            address:
               name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
      name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
      name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(309)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js

5.15s.

LINK . SPRINGER . COM {}