We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-69194-7_3.

Title:
Leukemia Stem Cells Microenvironment | SpringerLink
Description:
The dynamic interactions between leukemic cells and bone marrow (BM) cells in the leukemia BM microenvironment regulate leukemia stem cell (LSC) properties including localization, self-renewal, differentiation, and proliferation. Recent research of normal and...
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Keywords {🔍}

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Topics {✒️}

fatty acid oxidation haematopoietic stem-cell niche hypoxia-inducible factor-1alpha hematopoietic stem-cell niche nf-κb mediates chemoresistance hypoxia-activated prodrug pr-104 arginase-dependent immunosuppressive microenvironment jak2-v617f mutational status pml–ppar-δ pathway promote post-injury regeneration cxcl12-cxcr4 chemokine signaling dynamic chemotherapy-induced upregulation stem cell microenvironments angiopoietins-tie2 system osteoblastic cells regulate drug-resistant phenotype haematopoietic stem cells stroma-mediated dysregulation aml-induced osteogenic differentiation hematopoietic stem cells leukemia stem cells �malignancy-induced microenvironment” del cerro mh leukemic stem cells acute myeloid leukemia leukaemia-initiating cells adams gb leukemia bm microenvironments hyaluronic acid cooperate bone marrow niche privacy choices/manage cookies stem cell engraftment stem cell integrins rb regulates interactions induced myeloproliferative neoplasia �microenvironment-induced oncogenesis invasiveness-promoting molecule hartwell ka cancer stem cell acute lymphoblastic leukemia leukemia-specific dependence bone marrow microenvironment hypoxia regulates proliferation bone marrow osteoblasts calcium-sensing receptor mesenchymal cells pave cd44 integrates signaling normal stem cell cytokine-induced mobilization progenitor cell localization

Questions {❓}

Kuschel A, Simon P, Tug S (2012) Functional regulation of HIF-1α under normoxia--is there more than post-translational regulation?
Raaijmakers MH (2014) Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?

Schema {🗺️}

ScholarlyArticle:
      headline:Leukemia Stem Cells Microenvironment
      pageEnd:32
      pageStart:19
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-69194-7.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Stem Cell Microenvironments and Beyond
         isbn:
            978-3-319-69194-7
            978-3-319-69193-0
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yoko Tabe
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:Juntendo University Faculty of Medicine
                  address:
                     name:Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marina Konopleva
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Microenvironment, Stem cell, Niche
      description:The dynamic interactions between leukemic cells and bone marrow (BM) cells in the leukemia BM microenvironment regulate leukemia stem cell (LSC) properties including localization, self-renewal, differentiation, and proliferation. Recent research of normal and leukemia BM microenvironments has revealed several key components of specific niches that provide a sanctuary where subpopulations of leukemia cells evade chemotherapy-induced death and acquire a drug-resistant phenotype, as well as the molecular pathways critical for microenvironment/leukemia interactions. Although the biology of LSCs shares many similarities with that of normal hematopoietic stem cells (HSCs), LSCs are able to outcompete HSCs and hijack BM niches. Increasing evidence indicates that these niches fuel the growth of leukemia cells and contribute to therapeutic resistance and the metastatic potential of leukemia cells by shielding LSCs. Not only “microenvironment-induced oncogenesis,” but also a “malignancy-induced microenvironment” have been proposed. In this chapter, the key components and regulation of BM niches in leukemic BM is described. In addition, metabolic changes in LSCs, which are currently a subject of intense investigation, will also be discussed to understand LSC survival.
      datePublished:2017
      isAccessibleForFree:
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Book:
      name:Stem Cell Microenvironments and Beyond
      isbn:
         978-3-319-69194-7
         978-3-319-69193-0
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:Juntendo University Faculty of Medicine
      address:
         name:Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yoko Tabe
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:Juntendo University Faculty of Medicine
            address:
               name:Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Marina Konopleva
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Next Generation Hematology Laboratory Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan
      name:Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, USA
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