We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-57193-5_16.

Title:
Cell Death Mechanisms of Neurodegeneration | SpringerLink
Description:
There are common mechanisms shared by genetically or pathologically distinct neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. This...
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Schema {🗺️}

ScholarlyArticle:
      headline:Cell Death Mechanisms of Neurodegeneration
      pageEnd:425
      pageStart:403
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-57193-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Neurodegenerative Diseases
         isbn:
            978-3-319-57193-5
            978-3-319-57191-1
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jing Fan
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ted M. Dawson
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Valina L. Dawson
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Neurodegenerative diseases, Cell death, Oxidative stress, Excitotoxicity, Parthanatos, Mitochondria, Nitric oxide, AIF
      description:There are common mechanisms shared by genetically or pathologically distinct neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. This indicates that although the original cause may differ in individual diseases or even subtypes of certain disorders, these disrupted common cell functions and signaling, together with aging, may lead to final execution of cell death through similar pathways. The variable neurodegenerative disease symptoms are probably caused by the type, location, and connection of the cell populations that suffer from dysfunction and loss. Besides apoptosis, necroptosis, and autophagy, an important form of death termed parthanatos plays a prominent role in stroke and several neurodegenerative diseases, which is due to PARP-1 overactivation, PAR accumulation, nuclear translocation of the mitochondria protein AIF, and large-scale DNA cleavage. Understanding the mechanisms and interactions of cell death signaling will not only help to develop neuroprotective strategies to halt neurodegeneration, but also provide biomarkers for monitoring disease progression and recovery.
      datePublished:2017
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Book:
      name:Neurodegenerative Diseases
      isbn:
         978-3-319-57193-5
         978-3-319-57191-1
Organization:
      name:Springer International Publishing
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Johns Hopkins University School of Medicine
      address:
         name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jing Fan
      affiliation:
            name:Johns Hopkins University School of Medicine
            address:
               name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
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      name:Ted M. Dawson
      affiliation:
            name:Johns Hopkins University School of Medicine
            address:
               name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
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            name:Johns Hopkins University School of Medicine
            address:
               name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
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            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Valina L. Dawson
      affiliation:
            name:Johns Hopkins University School of Medicine
            address:
               name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins University School of Medicine
            address:
               name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
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            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
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      email:[email protected]
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      name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
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