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Title:
The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma | SpringerLink
Description:
The role of sigma 1 receptor (S1R) in glaucomaglaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
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Topics {✒️}

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Questions {❓}

Francardo V (2014) Sigma-1 receptor: a potential new target for Parkinson’s disease?

Schema {🗺️}

ScholarlyArticle:
      headline:The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma
      pageEnd:307
      pageStart:299
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-50174-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Sigma Receptors: Their Role in Disease and as Therapeutic Targets
         isbn:
            978-3-319-50174-1
            978-3-319-50172-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
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      author:
            name:Barbara Mysona
            affiliation:
                  name:Medical College of Georgia at Augusta University
                  address:
                     name:Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neil Kansara
            affiliation:
                  name:Medical College of Georgia at Augusta University
                  address:
                     name:Medical College of Georgia at Augusta University, Augusta, USA
                     type:PostalAddress
                  type:Organization
                  name:The James and Jean Culver Vision Discovery Institute
                  address:
                     name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing Zhao
            affiliation:
                  name:Medical College of Georgia at Augusta University
                  address:
                     name:Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, USA
                     type:PostalAddress
                  type:Organization
                  name:The James and Jean Culver Vision Discovery Institute
                  address:
                     name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kathryn Bollinger
            affiliation:
                  name:Medical College of Georgia at Augusta University
                  address:
                     name:Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, USA
                     type:PostalAddress
                  type:Organization
                  name:Augusta University
                  address:
                     name:Department of Cellular Biology and Anatomy, Augusta University, Augusta, USA
                     type:PostalAddress
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                     name:Medical College of Georgia at Augusta University, Augusta, USA
                     type:PostalAddress
                  type:Organization
                  name:The James and Jean Culver Vision Discovery Institute
                  address:
                     name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords: Glaucoma , Optic nerve , Retinal ganglion cell , Neurodegeneration , Neuroprotection
      description:The role of sigma 1 receptor (S1R) in glaucomaglaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseaseParkinson’s disease . S1R modulates multiple cellular functions associated with neurodegenerationneurodegeneration . These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stressoxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonistsAgonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.
      datePublished:2017
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Book:
      name:Sigma Receptors: Their Role in Disease and as Therapeutic Targets
      isbn:
         978-3-319-50174-1
         978-3-319-50172-7
Organization:
      name:Springer International Publishing
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      name:Medical College of Georgia at Augusta University
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         name:Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, USA
         type:PostalAddress
      name:Medical College of Georgia at Augusta University
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      name:The James and Jean Culver Vision Discovery Institute
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         name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
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         type:PostalAddress
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         name:Medical College of Georgia at Augusta University, Augusta, USA
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Person:
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            address:
               name:Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, USA
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      name:Neil Kansara
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               type:PostalAddress
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            name:The James and Jean Culver Vision Discovery Institute
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      name:Jing Zhao
      affiliation:
            name:Medical College of Georgia at Augusta University
            address:
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               type:PostalAddress
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      affiliation:
            name:Medical College of Georgia at Augusta University
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               type:PostalAddress
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               name:Department of Cellular Biology and Anatomy, Augusta University, Augusta, USA
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               name:Medical College of Georgia at Augusta University, Augusta, USA
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      name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
      name:Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, USA
      name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
      name:Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, USA
      name:Department of Cellular Biology and Anatomy, Augusta University, Augusta, USA
      name:Medical College of Georgia at Augusta University, Augusta, USA
      name:The James and Jean Culver Vision Discovery Institute, Augusta, USA
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