We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-22536-4_10.

Title:
Sonoporation: Concept and Mechanisms | SpringerLink
Description:
Contrast agents for ultrasound are now routinely used for diagnosis and imaging. In recent years, new promising possibilities for targeted drug delivery have been proposed that can be realized by using the microbubble composing ultrasound contrast agents (UCAs). The...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Sonoporation: Concept and Mechanisms
      pageEnd:189
      pageStart:175
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-22536-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Therapeutic Ultrasound
         isbn:
            978-3-319-22536-4
            978-3-319-22535-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ayache Bouakaz
            affiliation:
                  name:Université François-Rabelais de Tours
                  address:
                     name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Aya Zeghimi
            affiliation:
                  name:Université François-Rabelais de Tours
                  address:
                     name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander A. Doinikov
            affiliation:
                  name:Université François-Rabelais de Tours
                  address:
                     name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Sonoporation, Ultrasound, Microbubble, Mechanisms
      description:Contrast agents for ultrasound are now routinely used for diagnosis and imaging. In recent years, new promising possibilities for targeted drug delivery have been proposed that can be realized by using the microbubble composing ultrasound contrast agents (UCAs). The microbubbles can carry drugs and selectively adhere to specific sites in the human body. This capability, in combination with the effect known as sonoporation, provides great possibilities for localized drug delivery. Sonoporation is a process in which ultrasonically activated UCAs, pulsating nearby biological barriers (cell membrane or endothelial layer), increase their permeability and thereby enhance the extravasation of external substances. In this way drugs and genes can be delivered inside individual cells without serious consequences for the cell viability. Sonoporation has been validated both in-vitro using cell cultures and in-vivo in preclinical studies. However, today, the mechanisms by which molecules cross the biological barriers remain unrevealed despite a number of proposed theories. This chapter will provide a survey of the current studies on various hypotheses regarding the routes by which drugs are incorporated into cells or across the endothelial layer and possible associated microbubble acoustic phenomena.
      datePublished:2016
      isAccessibleForFree:
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Book:
      name:Therapeutic Ultrasound
      isbn:
         978-3-319-22536-4
         978-3-319-22535-7
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Université François-Rabelais de Tours
      address:
         name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
         type:PostalAddress
      name:Université François-Rabelais de Tours
      address:
         name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
         type:PostalAddress
      name:Université François-Rabelais de Tours
      address:
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Person:
      name:Ayache Bouakaz
      affiliation:
            name:Université François-Rabelais de Tours
            address:
               name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Aya Zeghimi
      affiliation:
            name:Université François-Rabelais de Tours
            address:
               name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
               type:PostalAddress
            type:Organization
      name:Alexander A. Doinikov
      affiliation:
            name:Université François-Rabelais de Tours
            address:
               name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
      name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
      name:Inserm Imaging and Ultrasound, INSERM U930, Imagerie et Cerveau, Université François-Rabelais de Tours, Tours, France
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