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Title:
Biology, Prognosis, and Therapy of Waldenström Macroglobulinemia | SpringerLink
Description:
Waldenström Macroglobulinemia (WM) is a rare B-cell lymphoma characterized by the uncontrolled accumulation of malignant lymphoplasmacytic cells, mainly in the bone marrow, and monoclonal IgM production. Despite its rarity, our understanding of the biology of...
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Schema {🗺️}

ScholarlyArticle:
      headline:Biology, Prognosis, and Therapy of Waldenström Macroglobulinemia
      pageEnd:195
      pageStart:177
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-13150-4.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Non-Hodgkin Lymphoma
         isbn:
            978-3-319-13150-4
            978-3-319-13149-8
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jorge J. Castillo
            affiliation:
                  name:Dana-Farber Cancer Institute, Harvard Medical School
                  address:
                     name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Irene M. Ghobrial
            affiliation:
                  name:Dana-Farber Cancer Institute, Harvard Medical School
                  address:
                     name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Steven P. Treon
            affiliation:
                  name:Dana-Farber Cancer Institute, Harvard Medical School
                  address:
                     name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Waldenström Macroglobulinemia, MYD88, CXCR4, Biology, Therapy, Survival
      description:Waldenström Macroglobulinemia (WM) is a rare B-cell lymphoma characterized by the uncontrolled accumulation of malignant lymphoplasmacytic cells, mainly in the bone marrow, and monoclonal IgM production. Despite its rarity, our understanding of the biology of this disease has improved significantly in recent years with the identification of recurrent mutations in the MYD88 and CXCR4 genes. Based on the diversity of clinical features observed in WM patients, therapy should be highly personalized having into account several factors such as age, co-morbidities, IgM levels, and presence of hyperviscosity, coagulopathy, cryoglobulinemia, or cold agglutinin disease. In this chapter, we review the recent advances in the biology of WM and the current therapeutic options for untreated and relapsed WM patients. Finally, we discuss the role of prognostic factors and current evidence supporting an improvement in the survival of WM patients in the last decade.
      datePublished:2015
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Book:
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      isbn:
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         978-3-319-13149-8
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      name:Springer International Publishing
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      name:Dana-Farber Cancer Institute, Harvard Medical School
      address:
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         type:PostalAddress
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      address:
         name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
         type:PostalAddress
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      name:Jorge J. Castillo
      affiliation:
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            address:
               name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Irene M. Ghobrial
      affiliation:
            name:Dana-Farber Cancer Institute, Harvard Medical School
            address:
               name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Steven P. Treon
      affiliation:
            name:Dana-Farber Cancer Institute, Harvard Medical School
            address:
               name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
      name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
      name:Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
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