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Title:
Bioreactors for Mammalian Cells | SpringerLink
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Cultivation of mammalian cells has become a routine technique. Nevertheless, design and layout of cell culture processes has to meet cell specific demands. Numerous bioreactors and cultivation systems for cell culture, either for production of biopharmaceuticals or...
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google, scholar, pubmed, cas, cell, biotechnol, culture, pörtner, cells, bioreactors, production, eng, mammalian, animal, engineering, eibl, bioreactor, eds, tissue, process, technology, prog, bioeng, cultivation, adv, biochem, monoclonal, springer, central, chapter, design, czermak, antibody, cytotechnology, methods, perfusion, largescale, chem, biol, ozturk, bioprocess, systems, recombinant, mixing, fedbatch, industrial, vol, weinheim, power, growth,
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- Hacker DL, Jesus M, Wurm FM (2009) 25 years of recombinant proteins from reactor-grown cells – where do we go from here?
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ScholarlyArticle:
headline:Bioreactors for Mammalian Cells
pageEnd:135
pageStart:89
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-10320-4.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Animal Cell Culture
isbn:
978-3-319-10320-4
978-3-319-10319-8
type:Book
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:R. Pörtner
affiliation:
name:Hamburg University of Technology
address:
name:Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Mammalian cells, Bioreactors, Process strategies, Tissue engineering
description:Cultivation of mammalian cells has become a routine technique. Nevertheless, design and layout of cell culture processes has to meet cell specific demands. Numerous bioreactors and cultivation systems for cell culture, either for production of biopharmaceuticals or for tissue engineering, have been developed. Due to the special characteristics of these cells specific solutions are required. Selection of a suitable type of cell culture bioreactor system and/or an appropriate operation mode (batch, fed-batch, and perfusion) is affected by technical, biological, economical and regulatory considerations. Obviously there is no single cultivation system suitable for all applications. Furthermore, to compare different bioreactor systems or operation modes experimentally for a certain application is time consuming and expensive. Therefore, selection of an appropriate bioreactor or cultivation system requires extensive knowledge and expertise. The following contribution gives an introduction to bioreactor systems and cultivation strategies applied.
datePublished:2015
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affiliation:
name:Hamburg University of Technology
address:
name:Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Hamburg, Germany
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