We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-07911-0_10.

Title:
IgA, IgA Receptors, and Their Anti-inflammatory Properties | SpringerLink
Description:
Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis at mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple receptors...
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Topics {✒️}

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ScholarlyArticle:
      headline:IgA, IgA Receptors, and Their Anti-inflammatory Properties
      pageEnd:235
      pageStart:221
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-07911-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
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            978-3-319-07910-3
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         name:Springer International Publishing
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      author:
            name:Sanae Ben Mkaddem
            affiliation:
                  name:Centre de Recherche sur l’Inflammation
                  address:
                     name:Inserm, U1149, Centre de Recherche sur l’Inflammation, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:CNRS ERL8252
                  address:
                     name:CNRS ERL8252, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:Sorbonne Paris Cité
                  address:
                     name:Université Paris Diderot, Sorbonne Paris Cité, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:Laboratoire d’Excellence Inflamex
                  address:
                     name:Laboratoire d’Excellence Inflamex, Paris, France
                     type:PostalAddress
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            type:Person
            name:Ivy Christou
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            name:Elisabetta Rossato
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            name:Laureline Berthelot
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                     name:Université Paris Diderot, Sorbonne Paris Cité, Paris, France
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                  address:
                     name:Laboratoire d’Excellence Inflamex, Paris, France
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            type:Person
            name:Agnès Lehuen
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                  name:Inserm, U1016, Institut Cochin
                  address:
                     name:Inserm, U1016, Institut Cochin, Paris, France
                     type:PostalAddress
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            type:Person
            name:Renato C. Monteiro
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                  address:
                     name:Laboratoire d’Excellence Inflamex, Paris, France
                     type:PostalAddress
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                  name:DHU Fire, Hôpital Bichat Claude Bernard
                  address:
                     name:Laboratoire Dysfonctionnements Immunitaires, DHU Fire, Hôpital Bichat Claude Bernard, Paris, France
                     type:PostalAddress
                  type:Organization
                  name:Faculté de Médecine Xavier Bichat
                  address:
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            email:[email protected]
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      keywords:Immunoglobulin A, ITAMi, Inflammation, FcαRI, SIGNR1
      description:Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis at mucosal surfaces and play a role in immune protection. IgA functions mainly through interaction with multiple receptors including IgA Fc receptor I (FcαRI), transferrin receptor 1 (CD71), asialoglycoprotein receptor (ASGPR), Fcα/μR, FcRL4, and DC-SIGN/SIGNR1. In this review we discuss recent data demonstrating anti-inflammatory functions of IgA through two receptors, the FcαRI and DC-SIGN/SIGNR1 interactions in the regulation of immunity. Serum monomeric IgA is able to mediate an inhibitory signal following the interaction with FcαRI. It results in partial phosphorylation of its FcRγ-ITAM and the recruitment of the tyrosine phosphatase SHP-1, which induces cell inhibition following the formation of intracellular clusters named inhibisomes. In contrast, cross-linking of FcαRI by multimeric ligands induces a full phosphorylation of the FcRγ-ITAM leading to the recruitment of the tyrosine kinase Syk and cell activation. In addition, secretory IgA can mediate a potent anti-inflammatory function following the sugar-dependent interaction with SIGNR1 on dendritic cells which induces an immune tolerance via regulatory T cell expansion. Overall, the anti-inflammatory effect of serum and secretory IgA plays a crucial role in the physiology and in the prevention of tissue damage in multiple autoimmune and inflammatory diseases.
      datePublished:2014
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Book:
      name:Fc Receptors
      isbn:
         978-3-319-07911-0
         978-3-319-07910-3
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      name:Centre de Recherche sur l’Inflammation
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      name:Laboratoire d’Excellence Inflamex, Paris, France
      name:Inserm, U1149, Centre de Recherche sur l’Inflammation, Paris, France
      name:CNRS ERL8252, Paris, France
      name:Université Paris Diderot, Sorbonne Paris Cité, Paris, France
      name:Laboratoire d’Excellence Inflamex, Paris, France
      name:Inserm, U1149, Centre de Recherche sur l’Inflammation, Paris, France
      name:CNRS ERL8252, Paris, France
      name:Université Paris Diderot, Sorbonne Paris Cité, Paris, France
      name:Laboratoire d’Excellence Inflamex, Paris, France
      name:Inserm, U1149, Centre de Recherche sur l’Inflammation, Paris, France
      name:CNRS ERL8252, Paris, France
      name:Université Paris Diderot, Sorbonne Paris Cité, Paris, France
      name:Laboratoire d’Excellence Inflamex, Paris, France
      name:Laboratoire d’Excellence Inflamex, Paris, France
      name:Inserm, U1016, Institut Cochin, Paris, France
      name:Inserm, U1149, Centre de Recherche sur l’Inflammation, Paris, France
      name:CNRS ERL8252, Paris, France
      name:Université Paris Diderot, Sorbonne Paris Cité, Paris, France
      name:Laboratoire d’Excellence Inflamex, Paris, France
      name:Laboratoire Dysfonctionnements Immunitaires, DHU Fire, Hôpital Bichat Claude Bernard, Paris, France
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