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Title:
NOTCH and Esophageal Squamous Cell Carcinoma | SpringerLink
Description:
Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research on its mechanisms, prevention, and therapy. Recent studies have shown that NOTCH mutations are commonly seen in human ESCC. This chapter summarizes our current...
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Topics {✒️}

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Schema {🗺️}

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      headline:NOTCH and Esophageal Squamous Cell Carcinoma
      pageEnd:68
      pageStart:59
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-55031-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Notch Signaling in Embryology and Cancer
         isbn:
            978-3-030-55031-8
            978-3-030-55030-1
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yong Li
            affiliation:
                  name:National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences
                  address:
                     name:Department of Thoracic Surgery, National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
                  address:
                     name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yahui Li
            affiliation:
                  name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
                  address:
                     name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoxin Chen
            affiliation:
                  name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
                  address:
                     name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill
                  address:
                     name:Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:NOTCH, Esophagus, Esophageal squamous cell carcinoma
      description:Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research on its mechanisms, prevention, and therapy. Recent studies have shown that NOTCH mutations are commonly seen in human ESCC. This chapter summarizes our current understanding of the NOTCH pathway in normal esophagus and in ESCC. In normal esophagus, NOTCH pathway regulates the development of esophageal squamous epithelium, in particular, squamous differentiation. Exposure to extrinsic and intrinsic factors, such as gastroesophageal reflux, alcohol drinking, and inflammation, downregulates the NOTCH pathway and thus inhibits squamous differentiation of esophageal squamous epithelial cells. In ESCC, NOTCH plays a dual role as both a tumor suppressor pathway and an oncogenic pathway. In summary, further studies are warranted to develop NOTCH activators for the prevention of ESCC and NOTCH inhibitors for targeted therapy of a subset of ESCC with activated NOTCH pathway.
      datePublished:2021
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      name:Notch Signaling in Embryology and Cancer
      isbn:
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         978-3-030-55030-1
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      name:Springer International Publishing
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         type:ImageObject
      name:National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences
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         name:Department of Thoracic Surgery, National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China
         type:PostalAddress
      name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
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         name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
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         name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
         type:PostalAddress
      name:Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill
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      affiliation:
            name:National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences
            address:
               name:Department of Thoracic Surgery, National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
            address:
               name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
               type:PostalAddress
            type:Organization
      name:Yahui Li
      affiliation:
            name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
            address:
               name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
               type:PostalAddress
            type:Organization
      name:Xiaoxin Chen
      affiliation:
            name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University
            address:
               name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
               type:PostalAddress
            type:Organization
            name:Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill
            address:
               name:Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
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      email:[email protected]
PostalAddress:
      name:Department of Thoracic Surgery, National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing, China
      name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
      name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
      name:Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, USA
      name:Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
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