We are analyzing https://link.springer.com/chapter/10.1007/978-3-030-27480-1_11.

Title:
Endurance and Brain Glycogen: A Clue Toward Understanding Central Fatigue | SpringerLink
Description:
Brain glycogen stored in astrocytes produces lactate as a neuronal energy source transported by monocarboxylate transporters (MCTs) to maintain neuronal functions, such as hippocampus-regulated memory formation. Although exercise activates brain neurons, the role of...
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Fitness & Wellness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, article, google, scholar, cas, brain, glycogen, central, exercise, soya, lactate, chapter, research, physiol, hypoglycemia, neurons, muscle, glucose, metabolism, fatigue, matsui, prolonged, blood, metab, content, endurance, astrocytes, neuronal, exhaustive, magistretti, human, cerebral, springer, privacy, cookies, information, publish, energy, memory, astrocytic, rat, atp, hippocampal, acid, neuroscience, flow, function, search, maintain, role,

Topics {✒️}

4-imino-d-arabinitol f1-6p month download article/chapter lactate-mediated glia-neuronal signalling propyl]-1h-indole-2-carboxamide long-term memory formation 156-km ultra-trail race α-cyano-4-hydroxycinnamate 5-hiaa astrocyte-neuron metabolic cooperation hippocampus-regulated memory formation understanding central fatigue central nervous system central fatigue factors profound insulin-induced hypoglycemia astrocyte-neuron lactate transport mariko soya & hideaki soya 4-imino-d-arabinitol privacy choices/manage cookies maintain neuronal functions kramer af astrocytic glycogen plays brain glycogen metabolism cerebral blood flow α-cyano-4-hydroxycinnamate increased serotonergic activity device instant download brain glycogen decreased brain glycogen decrease hypoglycemic neuronal death blood lactate levels central fatigue brain glycogen concentration brain glycogen decreases brain energy metabolism maintain endurance capacity lower endurance capacity plasma amino acids challenging exploratory research brain glycogen content plasma quinolinic acid older men mediated cerebral perturbations provoked advanced research initiative decreased hippocampal atp european economic area energy supply substrate adenine nucleotide degradation ventromedial hypothalamus contributes axon initial segment speed-correlated firing von faber-castell

Schema {🗺️}

ScholarlyArticle:
      headline:Endurance and Brain Glycogen: A Clue Toward Understanding Central Fatigue
      pageEnd:346
      pageStart:331
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-27480-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Brain Glycogen Metabolism
         isbn:
            978-3-030-27480-1
            978-3-030-27479-5
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Takashi Matsui
            affiliation:
                  name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
                  address:
                     name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Mariko Soya
            affiliation:
                  name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
                  address:
                     name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hideaki Soya
            affiliation:
                  name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
                  address:
                     name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Endurance exercise, Central fatigue, Brain glycogen, Lactate, Metabolomics
      description:Brain glycogen stored in astrocytes produces lactate as a neuronal energy source transported by monocarboxylate transporters (MCTs) to maintain neuronal functions, such as hippocampus-regulated memory formation. Although exercise activates brain neurons, the role of astrocytic glycogen in the brain during exercise remains unknown. Since muscle glycogen fuels active muscles during exercise, we hypothesized that astrocytic glycogen plays an energetic role in the brain during exercise to maintain endurance capacity through lactate transport. To explore this hypothesis, we have used a rat model of prolonged exercise, microwave irradiation for the accurate detection of brain glycogen, capillary electrophoresis-mass spectrometry-based metabolomics, and inhibitors of glycogenolysis (1,4-dideoxy-1,4-imino-d-arabinitol; DAB) and lactate transport (α-cyano-4-hydroxycinnamate; 4-CIN). During prolonged exhaustive exercise, muscle glycogen was depleted and brain glycogen decreased when associated with decreased blood glucose levels and increased serotonergic activity known as central fatigue factors, suggesting brain glycogen decrease as an integrative factor for central fatigue. Prolonged exhaustive exercise also increased MCT2 protein in the brain, which takes up lactate in neurons, just as muscle MCTs are increased. Metabolomics revealed that brain but not muscle adenosine triphosphate (ATP) was maintained with lactate and other glycogenolytic and glycolytic sources. Intracerebroventricular (icv) injection of DAB suppressed brain lactate production and decreased hippocampal ATP levels at exhaustion. An icv injection of 4-CIN also decreased hippocampal ATP, resulting in lower endurance capacity. Our findings provide direct evidence that astrocytic glycogen-derived lactate fuels the brain to maintain endurance capacity during exhaustive exercise. Brain ATP levels maintained by glycogen might serve as a possible defense mechanism for neurons in the exhausted state.
      datePublished:2019
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Brain Glycogen Metabolism
      isbn:
         978-3-030-27480-1
         978-3-030-27479-5
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
      address:
         name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
         type:PostalAddress
      name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
      address:
         name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
         type:PostalAddress
      name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
      address:
         name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Takashi Matsui
      affiliation:
            name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
            address:
               name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Mariko Soya
      affiliation:
            name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
            address:
               name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
               type:PostalAddress
            type:Organization
      name:Hideaki Soya
      affiliation:
            name:Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba
            address:
               name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
      name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
      name:Sport Neuroscience Division, Faculty of Health and Sport Sciences, Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(179)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js

CDN Services {📦}

Pbgrd

4.38s.

LINK . SPRINGER . COM {}