We are analyzing https://link.springer.com/chapter/10.1007/978-1-4899-0274-0_22.

Title:
Regulation of T Cell Activation by CD28 and CTLA4 | SpringerLink
Description:
T cell activation is initiated by engagement of the T cell receptor (TCR)-CD3 complex by antigen displayed by major histocompatibility complex (MHC) molecules expressed on the surface of an antigen presenting cell (APC). However, under most circumstances, this...
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Keywords {🔍}

google, scholar, cas, pubmed, article, cell, activation, ctla, thompson, chapter, human, journal, usa, immunology, cells, lymphocyte, regulation, noel, science, apoptosis, expression, privacy, cookies, content, information, publish, boise, antigen, death, download, freeman, ledbetter, june, springer, research, search, immune, book, surface, signal, signals, preview, access, immunity, nadler, green, gray, lindsten, usd, personal,

Topics {✒️}

multiple t-cell-derived lymphokines/cytokines hla-dr+ antigen-presenting cells month download article/chapter mature human t-cells antigen presenting cell privacy choices/manage cookies device instant download immune regulation vi bcl-2 messenger rna fas death factor crucial survival signals b7-dependent responses gwen knapp center google scholar cell culture model download preview pdf european economic area cell activation pathway essential immune-checkpoint conditions privacy policy cd3-mediated apoptosis cd28-mediated signaling major histocompatibility complex cd28- deficient mice accepting optional cookies journal finder publish mhc class i human medullary thymocytes human lymphoid tissues lymphocyte clonal anergy main content log immunoglobulin superfamily- ctla-4 chapter usd 29 chapter cite check access ethics access surface-mediated social media chapter mechanisms book series proliferative signals permissions reprints antigen displayed immunology research affiliations department cell activation mice deficient chapter log cd28 costimulation privacy policy

Schema {🗺️}

ScholarlyArticle:
      headline:Regulation of T Cell Activation by CD28 and CTLA4
      pageEnd:217
      pageStart:209
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4899-0274-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Mechanisms of Lymphocyte Activation and Immune Regulation VI
         isbn:
            978-1-4899-0274-0
            978-1-4899-0276-4
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Patricia J. Noel
            affiliation:
                  name:Gwen Knapp Center for Lupus and Immunology Research
                  address:
                     name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lawrence H. Boise
            affiliation:
                  name:Gwen Knapp Center for Lupus and Immunology Research
                  address:
                     name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Craig B. Thompson
            affiliation:
                  name:Gwen Knapp Center for Lupus and Immunology Research
                  address:
                     name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Chicago
                  address:
                     name:Howard Hughes Medical Institute Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Major Histocompatibility Complex, Programme Cell Death, Cell Death Pathway, Immune Homeostasis, Wildtype Mouse
      description:T cell activation is initiated by engagement of the T cell receptor (TCR)-CD3 complex by antigen displayed by major histocompatibility complex (MHC) molecules expressed on the surface of an antigen presenting cell (APC). However, under most circumstances, this initial signal is insufficient to induce a proliferative response. TCR engagement in the absence of a second or costimulatory signal can lead to a state of anergy or cell death1. CD28 is a T cell surface receptor capable of providing this critical second signal following ligation of the B7 family of counter-receptors that are expressed on APCs2,3. This interaction provides not only proliferative signals, but also crucial survival signals that are important for both initiation and maintenance of an immune response4,5.
      datePublished:1996
      isAccessibleForFree:
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Book:
      name:Mechanisms of Lymphocyte Activation and Immune Regulation VI
      isbn:
         978-1-4899-0274-0
         978-1-4899-0276-4
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Gwen Knapp Center for Lupus and Immunology Research
      address:
         name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
         type:PostalAddress
      name:Gwen Knapp Center for Lupus and Immunology Research
      address:
         name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
         type:PostalAddress
      name:Gwen Knapp Center for Lupus and Immunology Research
      address:
         name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
         type:PostalAddress
      name:The University of Chicago
      address:
         name:Howard Hughes Medical Institute Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Patricia J. Noel
      affiliation:
            name:Gwen Knapp Center for Lupus and Immunology Research
            address:
               name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
               type:PostalAddress
            type:Organization
      name:Lawrence H. Boise
      affiliation:
            name:Gwen Knapp Center for Lupus and Immunology Research
            address:
               name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
               type:PostalAddress
            type:Organization
      name:Craig B. Thompson
      affiliation:
            name:Gwen Knapp Center for Lupus and Immunology Research
            address:
               name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
               type:PostalAddress
            type:Organization
            name:The University of Chicago
            address:
               name:Howard Hughes Medical Institute Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
      name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
      name:Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, USA
      name:Howard Hughes Medical Institute Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, USA
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