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Title:
The Basis for Active Transport at the Blood-Brain Barrier | SpringerLink
Description:
Certain low molecular weight compounds have been shown to enter the brain by specific carrier-mediated transport systems in the endothelial cell membranes (1–4). At least eight such carriers capable of moving solutes from blood into brain have been described...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:The Basis for Active Transport at the Blood-Brain Barrier
      pageEnd:16
      pageStart:5
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4684-3752-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:The Cerebral Microvasculature
         isbn:
            978-1-4684-3752-2
            978-1-4684-3754-6
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:A. L. Betz
            affiliation:
                  name:University of Michigan
                  address:
                     name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Michigan
                  address:
                     name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:G. W. Goldstein
            affiliation:
                  name:University of Michigan
                  address:
                     name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Michigan
                  address:
                     name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Active Transport, Neutral Amino Acid, Brain Capillary, Brain Capillary Endothelial Cell, Large Neutral Amino Acid
      description:Certain low molecular weight compounds have been shown to enter the brain by specific carrier-mediated transport systems in the endothelial cell membranes (1–4). At least eight such carriers capable of moving solutes from blood into brain have been described (4). Most of the blood-brain barrier (BBB) transport systems that have been described are not able to move solutes against concentration gradients, but instead, facilitate the equilibration of brain and blood concentrations for their particular substrates. Although the BBB acts as an impermeable wall for some solutes and a passive sieve for others, it is generally agreed that an important function is active regulation of the internal milieu of the central nervous system (CNS) (3,5,6). Several reports have suggested that the BBB can mediate solute efflux from the brain against a concentration gradient (7–13), but these studies utilized intact animals and, consequently, their interpretation is made difficult by the presence of neurons, glia and choroid plexus.
      datePublished:1980
      isAccessibleForFree:
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Book:
      name:The Cerebral Microvasculature
      isbn:
         978-1-4684-3752-2
         978-1-4684-3754-6
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      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Michigan
      address:
         name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
         type:PostalAddress
      name:University of Michigan
      address:
         name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
         type:PostalAddress
      name:University of Michigan
      address:
         name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
         type:PostalAddress
      name:University of Michigan
      address:
         name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
         type:PostalAddress
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      name:A. L. Betz
      affiliation:
            name:University of Michigan
            address:
               name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
            name:University of Michigan
            address:
               name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:G. W. Goldstein
      affiliation:
            name:University of Michigan
            address:
               name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
            name:University of Michigan
            address:
               name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
      name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
      name:Department of Pediatrics, University Hospital, University of Michigan, Ann Arbor, USA
      name:Department of Neurology, University Hospital, University of Michigan, Ann Arbor, USA
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