We are analyzing https://link.springer.com/chapter/10.1007/978-1-4615-1321-6_11.

Title:
Molecular Mechanisms of Endothelial Dysfunction in the Diabetic Heart | SpringerLink
Description:
Healthy endothelium is thromboresistent, tight and supports vasodilatation by the release of various mediators such as nitric oxide and prostacyclin1–3. In addition, endothelium inhibits the proliferation of smooth muscle cells and migration of leukocytes...
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

google, scholar, article, cas, endothelial, pubmed, diabetes, nitric, oxide, cells, chapter, diabetic, rösen, dysfunction, vascular, synthase, role, apoptosis, glucose, biol, research, disease, heart, endothelium, cell, clin, human, expression, privacy, cookies, content, information, publish, sui, oxygen, download, invest, induction, springer, function, search, mechanisms, book, preview, hypertension, eds, med, stress, york, activation,

Topics {✒️}

transcription factor nf—kb/rel activated transcription factor-kappa nf—kb-dependent fashion endothelial ca2+/edrf signalling high d-glucose-induced ach-induced coronary vasodilatation month download article/chapter glucocorticoid-induced thymocytes apoptosis article google scholar cas google scholar related gene expression nitric oxide synthase antihemophilic factor antigen privacy choices/manage cookies cultured endothelial cells human endothelial cells device instant download vascular dysfunction induced coronary vascular reserve high glucose concentrations boniface research centre dna damage induced bovine endothelial cells endothelial cells based activate nf-kappa a-thioctic acid endothelium dependent relaxation smooth muscle cells vascular endothelial dysfunction european economic area receptors/binding proteins van de vusse arachidonic acid incorporation basic biological phenomenon gamma-irradiation leads subsequent biological effects diabetes research institute endothelial dysfunction coincides journal finder publish elevated glucose levels nf-kappab binding superoxide anion production download preview pdf conditions privacy policy blood flow sufficient diabetic rat heart adult rat heart highglucose-triggered apoptosis endogenous endonuclease activation accepting optional cookies

Questions {❓}

Baeuerle, Activate NF-kappa B or die?
Rösen, Generation of reactive oxygen intermediates, activation of NF-1(11, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?
Why does hyperglycemia induce the formation of reactive oxygen species?

Schema {🗺️}

ScholarlyArticle:
      headline:Molecular Mechanisms of Endothelial Dysfunction in the Diabetic Heart
      pageEnd:86
      pageStart:75
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4615-1321-6.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Diabetes and Cardiovascular Disease
         isbn:
            978-1-4615-1321-6
            978-1-4613-5496-3
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Peter Rösen
            affiliation:
                  name:Diabetes Research Institute
                  address:
                     name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xueliang Du
            affiliation:
                  name:Diabetes Research Institute
                  address:
                     name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhi Sui Guang
            affiliation:
                  name:Diabetes Research Institute
                  address:
                     name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Vascular Endothelial Growth Factor, Nitric Oxide, High Glucose, Human Umbilical Vein Endothelial Cell, Human Endothelial Cell
      description:Healthy endothelium is thromboresistent, tight and supports vasodilatation by the release of various mediators such as nitric oxide and prostacyclin1–3. In addition, endothelium inhibits the proliferation of smooth muscle cells and migration of leukocytes across the vessel wal14. Taken together, all these properties of healthy endothelium are necessary to maintain an intact circulation and a blood flow sufficient to supply tissues and organs not directly exposed to the blood stream with oxygen and nutrients1–6. Disturbances of these processes are often summarised as endothelial dysfunction and have been proposed to play a most important role for the development of vascular complications either in the form of micro-or macroangiopathy4–6
      datePublished:2001
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Diabetes and Cardiovascular Disease
      isbn:
         978-1-4615-1321-6
         978-1-4613-5496-3
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Diabetes Research Institute
      address:
         name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
         type:PostalAddress
      name:Diabetes Research Institute
      address:
         name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
         type:PostalAddress
      name:Diabetes Research Institute
      address:
         name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Peter Rösen
      affiliation:
            name:Diabetes Research Institute
            address:
               name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
               type:PostalAddress
            type:Organization
      name:Xueliang Du
      affiliation:
            name:Diabetes Research Institute
            address:
               name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
               type:PostalAddress
            type:Organization
      name:Zhi Sui Guang
      affiliation:
            name:Diabetes Research Institute
            address:
               name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
      name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
      name:Department of Clinical Biochemstry, Diabetes Research Institute, Düsseldorf, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(138)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js

4.03s.

LINK . SPRINGER . COM {}