We are analyzing https://link.springer.com/chapter/10.1007/978-1-4615-0193-0_65.

Title:
induction of apoptosis in mouse t cells upon peroxisome proliferator-activated receptor gamma (ppar-γ) binding | SpringerLink
Description:
Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear receptor transcription factors. PPARs heterodimerize with the retinoic acid X receptor upon ligand binding. This complex then binds to PPAR responsive elements (PPREs)...
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Schema {🗺️}

ScholarlyArticle:
      headline:induction of apoptosis in mouse t cells upon peroxisome proliferator-activated receptor gamma (ppar-γ) binding
      pageEnd:425
      pageStart:421
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4615-0193-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5
         isbn:
            978-1-4615-0193-0
            978-1-4613-4960-0
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Sarah G. Harris
            affiliation:
                  name:University of Rochester School of Medicine and Dentistry
                  address:
                     name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
                     type:PostalAddress
                  type:Organization
                  name:University of Rochester School of Medicine and Dentistry
                  address:
                     name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
                     type:PostalAddress
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            type:Person
            name:Richard P. Phipps
            affiliation:
                  name:University of Rochester School of Medicine and Dentistry
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                     name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
                     type:PostalAddress
                  type:Organization
                  name:University of Rochester School of Medicine and Dentistry
                  address:
                     name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Naive Mouse, Synthetic Ligand, Outer Membrane Leaflet, Colonic Tumor Cell Line, Mock Treated Control
      description:Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear receptor transcription factors. PPARs heterodimerize with the retinoic acid X receptor upon ligand binding. This complex then binds to PPAR responsive elements (PPREs) located in the promoter regions of various genes and acts to regulate their expression (Westin, et al., 1998). Although there are several PPARs, much attention has recently focused on PPAR-γ. Two isoforms of PPAR-γ have been found in mice - PPARγl and PPAR-γ2. PPAR-γ2 is found exclusively in adipose tissue and regulates adipogenesis. PPAR-γl, however, is expressed at low levels in many cells such as smooth muscle cells, macrophages, and epithelial cells (Ma, et al., 1998). Ligand binding of PPAR-γl has many functions including inhibition of migration of vascular smooth muscle cells, inhibition of inducible nitric oxide synthase in murine macrophages, and apoptosis of some colonic tumor cell lines (Kitamura, et al., 1999, Spiegelman, et al., 1997, Vedin, et al., 1996). Metabolites of prostaglandin D2 (PGD2) have been suggested to be natural ligands for PPAR-γ. For example, 15-deoxy-Δ12,14-PGJ2(herein referred to as 15-d-PGJ2) as well as other prostaglandins of the J series can bind and activate PPARγin vitro.Synthetic ligands for PPAR-yhave also been identified, and include the thiazoldinediones (i.e. ciglitazone, troglitazone) (Schoonjans, et al., 1997, Willson, et al., 1996). These compounds are anti-hyperglycemic drugs currently used to treat non-insulin dependent diabetes.
      datePublished:2002
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Book:
      name:Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5
      isbn:
         978-1-4615-0193-0
         978-1-4613-4960-0
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      name:Springer US
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         type:ImageObject
      name:University of Rochester School of Medicine and Dentistry
      address:
         name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
         type:PostalAddress
      name:University of Rochester School of Medicine and Dentistry
      address:
         name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
         type:PostalAddress
      name:University of Rochester School of Medicine and Dentistry
      address:
         name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
         type:PostalAddress
      name:University of Rochester School of Medicine and Dentistry
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         name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
         type:PostalAddress
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Person:
      name:Sarah G. Harris
      affiliation:
            name:University of Rochester School of Medicine and Dentistry
            address:
               name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
               type:PostalAddress
            type:Organization
            name:University of Rochester School of Medicine and Dentistry
            address:
               name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
               type:PostalAddress
            type:Organization
      name:Richard P. Phipps
      affiliation:
            name:University of Rochester School of Medicine and Dentistry
            address:
               name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
               type:PostalAddress
            type:Organization
            name:University of Rochester School of Medicine and Dentistry
            address:
               name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
      name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
      name:Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester
      name:Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester
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