We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-8289-5_1.

Title:
Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis | SpringerLink
Description:
The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. This protein and the other two members of this small gene family, Gadd45b and...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Karger S, Weidinger C, Krause K, Sheu SY, Aigner T, Gimm O, Schmid KW, Dralle H, Fuhrer D (2009) FOXO3a: a novel player in thyroid carcinogenesis?
Snyder AR, Morgan WF (2004) Gene expression profiling after irradiation: clues to understanding acute and persistent responses?

Schema {🗺️}

ScholarlyArticle:
      headline:Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis
      pageEnd:19
      pageStart:1
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-8289-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Gadd45 Stress Sensor Genes
         isbn:
            978-1-4614-8289-5
            978-1-4614-8288-8
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jesús M. Salvador
            affiliation:
                  name:Centro Nacional de Biotecnología
                  address:
                     name:Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joshua D. Brown-Clay
            affiliation:
                  name:Georgetown University
                  address:
                     name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Albert J. Fornace
            affiliation:
                  name:Georgetown University
                  address:
                     name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
                     type:PostalAddress
                  type:Organization
                  name:Georgetown University
                  address:
                     name:Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Proliferate Cell Nuclear Antigen, Ionize Radiation, Adenomatous Polyposis Coli, Nucleotide Excision Repair, Genotoxic Stress
      description:The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. This protein and the other two members of this small gene family, Gadd45b and Gadd45g, have been implicated in a variety of the responses to cell injury including cell cycle checkpoints, apoptosis, and DNA repair. In vivo, many of the prominent roles for the Gadd45 proteins are associated with signaling mediated by p38 mitogen-activated protein kinases (MAPK). Gadd45 proteins can contribute to p38 activation either by activation of upstream kinase(s) or by direct interaction. In vivo, there are important tissue and cell-type-specific differences in the roles for Gadd45 in MAPK signaling. In addition to being p53-regulated, Gadd45a has been found to contribute to p53 activation via p38. Like other stress and signaling proteins, Gadd45 proteins show complex regulation and numerous effectors.
      datePublished:2013
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Book:
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      isbn:
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         978-1-4614-8288-8
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      name:Springer New York
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         type:ImageObject
      name:Centro Nacional de Biotecnología
      address:
         name:Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain
         type:PostalAddress
      name:Georgetown University
      address:
         name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
         type:PostalAddress
      name:Georgetown University
      address:
         name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
         type:PostalAddress
      name:Georgetown University
      address:
         name:Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
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Person:
      name:Jesús M. Salvador
      affiliation:
            name:Centro Nacional de Biotecnología
            address:
               name:Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Joshua D. Brown-Clay
      affiliation:
            name:Georgetown University
            address:
               name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
               type:PostalAddress
            type:Organization
      name:Albert J. Fornace
      affiliation:
            name:Georgetown University
            address:
               name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
               type:PostalAddress
            type:Organization
            name:Georgetown University
            address:
               name:Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain
      name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
      name:Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA
      name:Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
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