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Title:
Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy | SpringerLink
Description:
The development of metastasis is the major cause of death in cancer patients. In certain instances, this occurs shortly after primary tumor detection and treatment, indicating these lesions were already expanding at the moment of diagnosis or initiated exponential...
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Questions {❓}

Hsu MY, Rovinsky S, Penmatcha S, Herlyn M, Muirhead D (2005) Bone morphogenetic proteins in melanoma: angel or devil?
Ranganathan AC, Adam AP, Zhang L, Aguirre-Ghiso JA (2006) Tumor cell dormancy induced by p38(SAPK) and ER-stress signaling: an adaptive advantage for metastatic cells?

Schema {🗺️}

ScholarlyArticle:
      headline:Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy
      pageEnd:89
      pageStart:73
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-1445-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Systems Biology of Tumor Dormancy
         isbn:
            978-1-4614-1445-2
            978-1-4614-1444-5
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Maria Soledad Sosa
            affiliation:
                  name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
                  address:
                     name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paloma Bragado
            affiliation:
                  name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
                  address:
                     name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jayanta Debnath
            affiliation:
                  name:University of California San Francisco
                  address:
                     name:Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julio A. Aguirre-Ghiso
            affiliation:
                  name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
                  address:
                     name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Quiescence, Minimal residual disease, Cellular stress, p38, MAPK, Metastasis
      description:The development of metastasis is the major cause of death in cancer patients. In certain instances, this occurs shortly after primary tumor detection and treatment, indicating these lesions were already expanding at the moment of diagnosis or initiated exponential growth shortly after. However, in many types of cancer, patients succumb to metastatic disease years and sometimes decades after being treated for a primary tumor. This has led to the notion that in these patients residual disease may remain in a dormant state. Tumor cell dormancy is a poorly understood phase of cancer progression and only recently have its underlying molecular mechanisms started to be revealed. Important questions that remain to be elucidated include not only which mechanisms prevent residual disease from proliferating but also which mechanisms critically maintain the long-term survival of these disseminated residual cells. Herein, we review recent evidence in support of genetic and epigenetic mechanisms driving dormancy. We also explore how therapy may cause the onset of dormancy in the surviving fraction of cells after treatment and how autophagy may be a mechanism that maintains the residual cells that are viable for prolonged periods.
      datePublished:2013
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Book:
      name:Systems Biology of Tumor Dormancy
      isbn:
         978-1-4614-1445-2
         978-1-4614-1444-5
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
      address:
         name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
         type:PostalAddress
      name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
      address:
         name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
         type:PostalAddress
      name:University of California San Francisco
      address:
         name:Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA
         type:PostalAddress
      name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
      address:
         name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Maria Soledad Sosa
      affiliation:
            name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
            address:
               name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Paloma Bragado
      affiliation:
            name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
            address:
               name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Jayanta Debnath
      affiliation:
            name:University of California San Francisco
            address:
               name:Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Julio A. Aguirre-Ghiso
      affiliation:
            name:Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine
            address:
               name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
      name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
      name:Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA
      name:Departments of Medicine and Otolaryngology, Tisch Cancer Institute, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA
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