We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-0106-3_12.

Title:
Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection | SpringerLink
Description:
Although nuclear factor-κB (NF-κB) is generally considered to be a pro-inflammatory transcription factor, recent studies indicate that it also plays a critical role in the development of an anti-inflammatory T cell subset called regulatory T (Treg...
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Schema {🗺️}

ScholarlyArticle:
      headline:Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection
      pageEnd:221
      pageStart:207
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-0106-3.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Current Topics in Innate Immunity II
         isbn:
            978-1-4614-0106-3
            978-1-4614-0105-6
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Qingguo Ruan
            affiliation:
                  name:University of Pennsylvania School of Medicine
                  address:
                     name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Youhai H. Chen
            affiliation:
                  name:University of Pennsylvania School of Medicine
                  address:
                     name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:NF-κB, c-Rel, Inflammation, Th17, Treg
      description:Although nuclear factor-κB (NF-κB) is generally considered to be a pro-inflammatory transcription factor, recent studies indicate that it also plays a critical role in the development of an anti-inflammatory T cell subset called regulatory T (Treg Treg ) cells. Two NF-κB proteins, c-Rel c-Rel and p65, drive the development of Treg Treg cells by promoting the formation of a Foxp3-specific enhanceosome. Consequently, c-Rel c-Rel -deficient mice have marked reductions in Treg Treg cells, and c-Rel c-Rel -deficient T cells are compromised in Treg Treg cell differentiation. However, with the exception of Foxp3, most NF-κB target genes in immune cells are pro-inflammatory. These include several Th17 Th17 -related cytokine genes and the retinoid-related orphan receptor-γ (Rorg or Rorc) that specifies Th17 Th17 differentiation and lineage-specific function. T cells deficient in c-Rel c-Rel or p65 are significantly compromised in Th17 Th17 differentiation, and c-Rel c-Rel -deficient mice are defective in Th17 Th17 responses. Thus, NF-κB is required for the development of both anti-inflammatory Treg Treg and pro-inflammatory Th17 Th17 cells.
      datePublished:2012
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Book:
      name:Current Topics in Innate Immunity II
      isbn:
         978-1-4614-0106-3
         978-1-4614-0105-6
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pennsylvania School of Medicine
      address:
         name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:University of Pennsylvania School of Medicine
      address:
         name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Qingguo Ruan
      affiliation:
            name:University of Pennsylvania School of Medicine
            address:
               name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Youhai H. Chen
      affiliation:
            name:University of Pennsylvania School of Medicine
            address:
               name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
      name:Department of Pathology and Laboratory Medicine, 712 Stellar-Chance Laboratories, University of Pennsylvania School of Medicine, Philadelphia, USA
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