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Title:
Epigenetic Regulation of Pluripotency | SpringerLink
Description:
Epigenetic regulation refers to the mechanisms that alter gene expression patterns in the absence of changes in the nucleotide sequence of the DNA molecule. The best understood epigenetic marks include posttranslational modifications of the histone tails and DNA...
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Keywords {🔍}

google, scholar, pubmed, cas, cell, cells, stem, embryonic, methylation, dna, histone, epigenetic, nature, chromatin, biol, nat, mol, pluripotency, gene, pluripotent, genet, rev, genes, chapter, regulation, human, dev, polycomb, mouse, biology, meissner, differentiation, expression, development, transcriptional, genome, developmental, lysine, complex, privacy, cookies, content, information, publish, modifications, download, usa, shen, transcription, mikkelsen,

Topics {✒️}

cell-type-specific manner allele-specific noncpg methylation lineage-specific polycomb targets positive-acting histone modifications nuclear adp-ribosylation reactions embryonic stem-cell lines month download article/chapter jarid2/jumonji coordinates control springer science+business media cold spring harbor privacy choices/manage cookies de novo methylation histone lysine methylation early mouse embryo promoter dna methylation device instant download embryonic stem cells induces histone hyperacetylation regulating gene expression jarid2 regulates binding human dna methylomes pluripotent cell line linking dna methylation genome-wide maps pluripotent stem cells embryonic stem cell protein interaction network swi/snf results dna methyltransferase 3a single-nucleotide resolution stem-cell identity ezh1 mediates methylation teratocarcinoma stem cells editor information editors de novo establishment dna methylation patterns zinc finger gene target gene occupancy eukaryotic cytosine methyltransferases core transcriptional network genomic dna methylation lineage-committed cells european economic area play central roles clinically relevant populations post-implantation epiblast adult fibroblast cultures shows dynamic interplay nurd component mbd3 rbp2 h3k4 demethylase

Questions {❓}

How is pluripotency determined and maintained?
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

Schema {🗺️}

ScholarlyArticle:
      headline:Epigenetic Regulation of Pluripotency
      pageEnd:40
      pageStart:26
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4419-7037-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:The Cell Biology of Stem Cells
         isbn:
            978-1-4419-7037-4
            978-1-4419-7036-7
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Eleni M. Tomazou
            affiliation:
                  name:Harvard University
                  address:
                     name:Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander Meissner
            affiliation:
                  name:Harvard University
                  address:
                     name:Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Embryonic Stem Cell, Methylation Level, Epigenetic Regulation, Human Embryonic Stem Cell, Inner Cell Mass
      description:Epigenetic regulation refers to the mechanisms that alter gene expression patterns in the absence of changes in the nucleotide sequence of the DNA molecule. The best understood epigenetic marks include posttranslational modifications of the histone tails and DNA methylation. Both play central roles in normal development and in diseases. Pluripotent stem cells have great promise for regenerative medicine and recent efforts have focused on identifying molecular networks that govern pluripotency. This chapter provides an overview of epigenetic regulation in embryonic stem cells. We present a brief introduction into epigenetic mechanisms and focus on their role in pluripotent cells.
      datePublished:2010
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            name:Harvard University
            address:
               name:Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, USA
               type:PostalAddress
            type:Organization
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      name:Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, USA
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