We are analyzing https://link.springer.com/chapter/10.1007/978-1-4419-6082-5_13.

Title:
Molecular Signatures of Hepatocellular Carcinoma Metastasis | SpringerLink
Description:
Metastasis is a significant contributor to morbidity and mortality among cancer patients. Such patients are often considered incurable with treatments offering either supportive care or aggressive management without curative intent. Over the last several decades,...
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Keywords {🔍}

scholar, google, pubmed, article, cas, cancer, hepatocellular, carcinoma, metastasis, cell, cells, human, expression, microrna, liver, res, molecular, breast, tumor, usa, carcinogenesis, metastatic, sci, med, nature, nat, analysis, chapter, budhu, patients, gene, oncol, proc, natl, acad, clin, wang, progression, genes, engl, survival, rev, genetics, forgues, science, lee, privacy, cookies, content, information,

Topics {✒️}

precursor microrna-155/bic rna alpha-fetoprotein expression defines macrophage-colony stimulating factor macrophage colony-stimulating factor wnt-ß-catenin signaling effective anti-metastasis therapies tumor-infiltrating immune cells targeted anti-metastasis therapies genome-wide microsatellite analysis stem/progenitor cell features genome-wide search liver cancer-derived hepatitis gene expression profiling privacy choices/manage cookies primary solid tumors o' connor sm human micro-rna gene expression profiles hepatic progenitor cells calin ga human lung cancers chapter molecular genetics hepatic damage induced editor information editors human breast tumours aggressive tumour phenotype human glioblastoma cells molecularly targeted agents circulating tumor cells gene-expression signature chronic lymphocytic leukemia tumor cells treated progenitor cell origin human hepatocellular carcinoma human breast cancer peritumoral liver tissue cancer stem cells preexisting variant cells latent disseminated cells european economic area epithelial-mesenchymal transition harris jf chambers af comparative lesion sequencing holst pellekaan ng adaptation versus selection epithelial-mesenchymal transitions unknown primary tumours supervised machine learning allelic imbalance regions

Questions {❓}

Wang XW and Thorgeirsson SS (2009) Transcriptome analysis of liver cancer: ready for the clinic?

Schema {🗺️}

ScholarlyArticle:
      headline:Molecular Signatures of Hepatocellular Carcinoma Metastasis
      pageEnd:257
      pageStart:241
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4419-6082-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Molecular Genetics of Liver Neoplasia
         isbn:
            978-1-4419-6082-5
            978-1-4419-6081-8
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Anuradha Budhu
            affiliation:
                  name:National Cancer Institute, NIH
                  address:
                     name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Xin Wei Wang
            affiliation:
                  name:National Cancer Institute
                  address:
                     name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Liver Cancer, Hepatocellular Carcinoma, Metastasis, Molecular signature, Microarray
      description:Metastasis is a significant contributor to morbidity and mortality among cancer patients. Such patients are often considered incurable with treatments offering either supportive care or aggressive management without curative intent. Over the last several decades, research in the metastasis field has expanded our knowledge of cancer progression mechanisms; however, the translation of this knowledge into effective anti-metastasis therapies has not been swift. In fact, to add to the complexity of metastasis, recent findings have challenged the classic notion of clonal evolution whereby liver metastases develop during late stages of carcinogenesis. In this chapter, we evaluate several metastasis models and where applicable, describe how high-throughput molecular profiling technology has shed light on and provided prognostic value for this multifaceted process, with emphasis on the liver. The resolution of metastasis will have a large impact on clinical advances, specifically in targeted anti-metastasis therapies to benefit patients.
      datePublished:2010
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Book:
      name:Molecular Genetics of Liver Neoplasia
      isbn:
         978-1-4419-6082-5
         978-1-4419-6081-8
Organization:
      name:Springer New York
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      name:National Cancer Institute, NIH
      address:
         name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA
         type:PostalAddress
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      address:
         name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, USA
         type:PostalAddress
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      name:Anuradha Budhu
      affiliation:
            name:National Cancer Institute, NIH
            address:
               name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xin Wei Wang
      affiliation:
            name:National Cancer Institute
            address:
               name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA
      name:Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, USA
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