We are analyzing https://link.springer.com/chapter/10.1007/978-1-4419-1399-9_16.

Title:
Mertk in Daily Retinal Phagocytosis: A History in the Making | SpringerLink
Description:
It took 62 years from the description of the retinal dystrophy in rats from the Royal College of Surgeons (RCS) strain to the discovery of the molecular defect underlying the phenotype. Phagocytosis of photoreceptor outer segments (POS) by retinal pigment epithelial...
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Keywords {🔍}

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Topics {✒️}

month download article/chapter de la recherche retinal degenerative diseases retinal pigment epithelial de la technologie retinal pigment epithelium daily retinal phagocytosis privacy choices/manage cookies pigment epithelium determined rod outer segment outer segment phagocytosis hall mo kirchgessner research grant diurnal retinal phagocytosis synchronized retinal phagocytosis inherited retinal dystrophy steady-state levels device instant download rod outer segments retinal dystrophy caused nih grants ey13295 mer tyrosine kinase linked signaling pathways altered signaling pathways photoreceptor outer segments physiological cell adhesion receptor tyrosine kinases fondation bettencourt schueller fondation des aveugles c-mer gene molecular defect underlying links apoptotic cells regulates αvβ5 binding retinal dystrophy phenotype european economic area wild-type mice circadian disc shedding mullen rj mfg-e8 université rené descartes mary greeve scholarship author information authors editor information editors drastic photoreceptor degeneration experimental rat chimeras conditions privacy policy integrin-bound photoreceptors mertk ligands gas6 mertk triggers uptake linkage group iv

Schema {🗺️}

ScholarlyArticle:
      headline:Mertk in Daily Retinal Phagocytosis: A History in the Making
      pageEnd:140
      pageStart:133
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4419-1399-9.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Retinal Degenerative Diseases
         isbn:
            978-1-4419-1399-9
            978-1-4419-1398-2
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Emeline F. Nandrot
            affiliation:
                  name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06
                  address:
                     name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06, Paris, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Eric M. Dufour
            affiliation:
                  name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06
                  address:
                     name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Retinal Pigment Epithelial, Focal Adhesion Kinase, Retinal Pigment Epithelial Cell, Retinitis Pigmentosa, Retinal Dystrophy
      description:It took 62 years from the description of the retinal dystrophy in rats from the Royal College of Surgeons (RCS) strain to the discovery of the molecular defect underlying the phenotype. Phagocytosis of photoreceptor outer segments (POS) by retinal pigment epithelial (RPE) cells follows a daily rhythm with a peak of activity 1.5–2 h after light onset for rod photoreceptors. We identified a deletion in the Mer tyrosine kinase (MerTK) receptor in RCS rat that abolishes internalization of POS by RPE cells. Accumulation of debris in the subretinal space then leads to drastic photoreceptor degeneration and rapid loss of vision. Interestingly, in wild-type mice and rats, MerTK is phosphorylated at the time of the phagocytic peak. We also demonstrated that the couple αvβ5 integrin receptor and MFG-E8 ligand synchronizes daily retinal phagocytosis. Indeed, when either one is absent in knockout mice, phagocytosis follows steady-state levels, and peak activation of integrin-associated protein and of MerTK does not occur. We now have a more precise picture of the sequence of molecular events governing retinal phagocytosis. However, requirement of MerTK ligands in vivo and linked signaling pathways still remain elusive so far.
      datePublished:2010
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Book:
      name:Retinal Degenerative Diseases
      isbn:
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         978-1-4419-1398-2
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      name:Springer New York
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06
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      name:Emeline F. Nandrot
      affiliation:
            name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06
            address:
               name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06, Paris, France
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Eric M. Dufour
      affiliation:
            name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06
            address:
               name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06, Paris, France
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06, Paris, France
      name:Centre de Recherche Institut de la Vision, UMR_S968, Inserm, UPMC University of Paris 06, Paris, France
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