We are analyzing https://link.springer.com/chapter/10.1007/978-1-4020-6554-5_7.

Title:
Trail Receptors: Targets for Cancer Therapy | SpringerLink
Description:
A human tumor cell's ability to avoid the normal regulatory mechanisms of cell growth, division, and death are the hallmarks of transformation and cancer. Numerous novel therapeutic agents currently in preclinical or clinical evaluation aim to revive the normal...
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Keywords {🔍}

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Topics {✒️}

tnf-related apoptosis-inducing ligand tnf-related apoptosis-inducing ligand related apoptosis-inducing ligand tumour-necrosis factor superfamily apo2 ligand/trail-induced apoptosis death-inducing signaling complex trail/apo-2l tumour necrosis factor death ligand-mediated apoptosis histone deacetylase inhibitors–development high-resolution x-ray structure enhancing trail-induced apoptosis interleukin-1beta-converting enzyme membrane-targeted death ligand caspase/direct iap-binding protein histone deacetylase inhibitors apo2l/trail-mediated apoptosis trail/apo2l-mediated apoptosis bortezomib-induced cell death trail/apo-2 ligand tnfalpha-mediated cell death death receptor–induced apoptosis activate nf-kappab tnf-family death receptors trail-mediated cell death month download article/chapter apo2l/trail-induced apoptosis regulate agonist-specific mechanisms signal fadd-dependent apoptosis distinct cross-linking requirements small-cell lung cancer anticancer drug-induced apoptosis tumor cell apoptosis ionizing irradiation-induced apoptosis monocyte-mediated tumoricidal activity modulates chemotherapy-induced apoptosis etoposide-induced apoptosis cellular flice-inhibitory protein inhibits tumor growth dr5-mediated apoptosis recombinant apo2l/trail versions ovarian tumor lines apo2l/trail-dependent recruitment chemoresistant bcl-2-overexpressing cells tumor-cell resistance hormone-refractory prostate cancer human tumor cell' apo-2 ligand human tumor cells proteasome inhibitor bortezomib

Schema {🗺️}

ScholarlyArticle:
      headline:Trail Receptors: Targets for Cancer Therapy
      pageEnd:158
      pageStart:127
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4020-6554-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Programmed Cell Death in Cancer Progression and Therapy
         isbn:
            978-1-4020-6554-5
            978-1-4020-6553-8
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Robin C. Humphreys
            affiliation:
                  name:Human Genome Sciences
                  address:
                     name:Development Sciences and Research, Human Genome Sciences, Rockville, USA
                     type:PostalAddress
                  type:Organization
                  name:Human Genome Sciences
                  address:
                     name:Oncology Research Department, Human Genome Sciences, Rockville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wendy Halpern
            affiliation:
                  name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology
                  address:
                     name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology, Rockville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:apoptosis, monoclonal antibody, agonist, TRAIL, TRAIL receptor
      description:A human tumor cell's ability to avoid the normal regulatory mechanisms of cell growth, division, and death are the hallmarks of transformation and cancer. Numerous novel therapeutic agents currently in preclinical or clinical evaluation aim to revive the normal regulation or evade these regulatory defects and induce growth arrest and cell death. One of the cell death pathways that has garnered significant interest, as a potential target for therapeutic intervention, is the programmed cell death pathway regulated by the tumor necrosis factor-related apoptosis-inducing ligand receptors (TRAIL-RS). Receptor agonist molecules including forms of the native ligand and monoclonal antibodies are being developed and tested as therapeutics in the treatment of human cancer.
      datePublished:2008
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Book:
      name:Programmed Cell Death in Cancer Progression and Therapy
      isbn:
         978-1-4020-6554-5
         978-1-4020-6553-8
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Human Genome Sciences
      address:
         name:Development Sciences and Research, Human Genome Sciences, Rockville, USA
         type:PostalAddress
      name:Human Genome Sciences
      address:
         name:Oncology Research Department, Human Genome Sciences, Rockville, USA
         type:PostalAddress
      name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology
      address:
         name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology, Rockville, USA
         type:PostalAddress
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Person:
      name:Robin C. Humphreys
      affiliation:
            name:Human Genome Sciences
            address:
               name:Development Sciences and Research, Human Genome Sciences, Rockville, USA
               type:PostalAddress
            type:Organization
            name:Human Genome Sciences
            address:
               name:Oncology Research Department, Human Genome Sciences, Rockville, USA
               type:PostalAddress
            type:Organization
      name:Wendy Halpern
      affiliation:
            name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology
            address:
               name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology, Rockville, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Development Sciences and Research, Human Genome Sciences, Rockville, USA
      name:Oncology Research Department, Human Genome Sciences, Rockville, USA
      name:Human Genome Sciences, Pathology, Pharmacokinetics and Toxicology, Rockville, USA
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