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Title:
The Vascular Actions of Relaxin | SpringerLink
Description:
Relaxin is emerging as a hormone with important vascular actions. Much of our recently gained knowledge of relaxin in this context has stemmed from investigations of maternal vascular adaptations to pregnancy in which the hormone is turning out to be an important...
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

l-arginine-nitric oxide pathway extracellular matrix-degrading phenotype springer science+business media nitric oxide-mediated mechanism t-tube model parameters relaxin-1-deficient mice develop month download article/chapter uterine growth-promoting effects 32p-labeled human relaxin twelve-day pregnant rat relaxin-induced renal vasodilation relaxin-mediated renal vasodilation specific relaxin-binding cells specific relaxin-binding sites relaxin-treated nonpregnant rats relaxin stimulates expression privacy choices/manage cookies matrix metalloproteinase-2 activity nitric oxide pathway nitric oxide generation nitric oxide synthesis coronary endothelial cells recombinant human relaxin myocardial injury caused decreases myogenic reactivity device instant download resistance blood vessels nitric oxide production future relaxin research relaxin deficient mice human uterine cells inhibits lung fibrosis relaxin modulates synthesis human dermal fibroblasts human lung fibroblasts splanchnic artery occlusion editor information editors pulsatile arterial load isolated uterine arteries relaxin counteracts asthma induces fast relaxation human arteries mediated human umbilical artery short term administration abnormal uterine function maternal vascular adaptations relaxin-induced reduction unemori en increased myocardial collagen endometrial blood vessels

Questions {❓}

Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?

Schema {🗺️}

ScholarlyArticle:
      headline:The Vascular Actions of Relaxin
      pageEnd:87
      pageStart:65
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-74672-2.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Relaxin and Related Peptides
         isbn:
            978-0-387-74672-2
            978-0-387-74670-8
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Arundhathi Jeyabalan
            affiliation:
                  name:University of Pittsburgh School of Medicine Magee-Womens Research Institute
                  address:
                     name:Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine Magee-Womens Research Institute, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sanjeev G. Shroff
            affiliation:
                  name:University of Pittsburgh Pittsburgh
                  address:
                     name:Department of Bioengineering, University of Pittsburgh Pittsburgh, Pennsylvania, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jaqueline Novak
            affiliation:
                  name:Walsh University
                  address:
                     name:Department of Biology, Walsh University, Canton, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kirk P. Conrad
            affiliation:
                  name:University of Florida College of Medicine
                  address:
                     name:Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Renal Vasodilation, Renal Circulation, Relaxin Receptor, Myogenic Reactivity, Cardiac Anaphylaxis
      description:Relaxin is emerging as a hormone with important vascular actions. Much of our recently gained knowledge of relaxin in this context has stemmed from investigations of maternal vascular adaptations to pregnancy in which the hormone is turning out to be an important mediator. This chapter is separated into three parts. In Part 1, we discuss relaxin in the setting of normal vascular function and focus on systemic hemodynamics and arterial mechanical properties, renal and other peripheral circulations, angiogenesis, as well as the cellular mechanisms of the vasodilatory actions of relaxin. In this section, we also summarize the evidence for an arterial-derived relaxin ligand-receptor system. In Part 2, we present relaxin in the context of vascular dysfunction and the implications for relaxin as a therapeutic agent in renal and cardiac diseases, ischemia and reperfusion injury, pulmonary hypertension, vascular inflammation and preeclampsia. Finally, in Part 3, we highlight some of the controversies and unresolved issues, as well as suggest a general direction for future relaxin research that is urgendy needed.
      datePublished:2007
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Book:
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      isbn:
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         978-0-387-74670-8
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      name:Springer New York
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pittsburgh School of Medicine Magee-Womens Research Institute
      address:
         name:Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine Magee-Womens Research Institute, Pittsburgh, USA
         type:PostalAddress
      name:University of Pittsburgh Pittsburgh
      address:
         name:Department of Bioengineering, University of Pittsburgh Pittsburgh, Pennsylvania, USA
         type:PostalAddress
      name:Walsh University
      address:
         name:Department of Biology, Walsh University, Canton, USA
         type:PostalAddress
      name:University of Florida College of Medicine
      address:
         name:Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA
         type:PostalAddress
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Person:
      name:Arundhathi Jeyabalan
      affiliation:
            name:University of Pittsburgh School of Medicine Magee-Womens Research Institute
            address:
               name:Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine Magee-Womens Research Institute, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Sanjeev G. Shroff
      affiliation:
            name:University of Pittsburgh Pittsburgh
            address:
               name:Department of Bioengineering, University of Pittsburgh Pittsburgh, Pennsylvania, USA
               type:PostalAddress
            type:Organization
      name:Jaqueline Novak
      affiliation:
            name:Walsh University
            address:
               name:Department of Biology, Walsh University, Canton, USA
               type:PostalAddress
            type:Organization
      name:Kirk P. Conrad
      affiliation:
            name:University of Florida College of Medicine
            address:
               name:Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine Magee-Womens Research Institute, Pittsburgh, USA
      name:Department of Bioengineering, University of Pittsburgh Pittsburgh, Pennsylvania, USA
      name:Department of Biology, Walsh University, Canton, USA
      name:Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA
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