We are analyzing https://link.springer.com/chapter/10.1007/978-0-387-72232-0_13.

Title:
IgA-Associated Diseases | SpringerLink
Description:
In many species, including humans, IgA is produced in quantities that far exceed the combined synthesis of all other immunoglobulin (Ig) isotypes (Conley and Delacrox, 1987; Mestecky et al., 2005). It is estimated that in humans, <66 mg/ kg body weight (i.e.,...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Familial selective IgA deficiency with circulating anti-IgA antibodies: a distinct group of patients?
Intravascular and mucosal immunoglobulin A: Two separate but related systems of immune defense?
Is selective IgA deficiency associated with central HLA genes or alleles of the DR-DQ region?

Schema {🗺️}

ScholarlyArticle:
      headline:IgA-Associated Diseases
      pageEnd:344
      pageStart:321
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-72232-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Mucosal Immune Defense: Immunoglobulin A
         isbn:
            978-0-387-72232-0
            978-0-387-72231-3
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jiri Mestecky
            affiliation:
                  name:University of Alabama at Birmingham
                  address:
                     name:Departments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lennart Hammarström
            affiliation:
                  name:Huddinge University Hospital, Karolinska Institute
                  address:
                     name:Department of Clinical Immunology, Huddinge University Hospital, Karolinska Institute, Sweden
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Multiple Myeloma, Mesangial Cell, Common Variable Immunodeficiency, IgAN Patient, Asialoglycoprotein Receptor
      description:In many species, including humans, IgA is produced in quantities that far exceed the combined synthesis of all other immunoglobulin (Ig) isotypes (Conley and Delacrox, 1987; Mestecky et al., 2005). It is estimated that in humans, <66 mg/ kg body weight (i.e., 4–5 g in a 70-kg adult) is produced daily, in contrast with ~25 mg/kg/day for IgG and much less for other isotypes. IgA displays diverse metabolic properties due to its heterogeneity of molecular forms (two subclasses, both of which can form monomers and polymers) and two distinct major sites of production (bone marrow and mucosal tissues) (Mestecky et al., 2005).
      datePublished:2007
      isAccessibleForFree:
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Book:
      name:Mucosal Immune Defense: Immunoglobulin A
      isbn:
         978-0-387-72232-0
         978-0-387-72231-3
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Alabama at Birmingham
      address:
         name:Departments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, USA
         type:PostalAddress
      name:Huddinge University Hospital, Karolinska Institute
      address:
         name:Department of Clinical Immunology, Huddinge University Hospital, Karolinska Institute, Sweden
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Jiri Mestecky
      affiliation:
            name:University of Alabama at Birmingham
            address:
               name:Departments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, USA
               type:PostalAddress
            type:Organization
      name:Lennart Hammarström
      affiliation:
            name:Huddinge University Hospital, Karolinska Institute
            address:
               name:Department of Clinical Immunology, Huddinge University Hospital, Karolinska Institute, Sweden
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Departments of Microbiology and Medicine, University of Alabama at Birmingham, Birmingham, USA
      name:Department of Clinical Immunology, Huddinge University Hospital, Karolinska Institute, Sweden
WebPageElement:
      isAccessibleForFree:
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