We are analyzing https://link.springer.com/chapter/10.1007/978-0-387-72005-0_13.

Title:
Role of Altered Expression of HLA Class I Molecules in Cancer Progression | SpringerLink
Description:
HLA class I antigens play a key role in immune recognition of transformed and virally infected cells via binding to the peptides of “non-self” or aberrantly expressed proteins and subsequent presentation of the newly formed “HLA-I-peptide”...
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Keywords {🔍}

article, cancer, cas, google, scholar, hla, pubmed, class, garrido, tumor, cabrera, ruizcabello, antigens, loss, expression, immunol, immune, cells, cell, immunology, escape, melanoma, antigen, human, nature, privacy, cookies, content, information, publish, paper, altered, clinical, tissue, download, chapter, lopeznevot, springer, analysis, research, search, role, aptsiauri, mendez, mechanisms, immunosurveillance, preview, access, immunotherapy, mhc,

Topics {✒️}

intratumoral cytokines/chemokines/growth factors francisco ruiz-cabello & federico garrido immune-mediated diseases month download article/chapter beta2-microglobulin gene mutations beta2-microglobulin loh analysis /beta2-microglobulin complex successive mutational events privacy choices/manage cookies cell-based immunotherapy derivative cell lines paper aptsiauri device instant download editor information editors multiple genetic alterations antigen presentation machinery paper cite tumor cell elimination tumor cell surface altered hla class angel garcia-lor european economic area aberrantly expressed proteins van der ven van der slik van der zwan continuing medical education human tumor tissues �tumor escape” phenotypes polymorphic hla class download preview pdf shaping tumor immunogenicity underlying molecular mechanisms defects cancer progression hla haplotype loss conditions privacy policy human solid tumors chromosome region 6p21 virally infected cells limits clinical outcome antigenic determinant loss hla-abc loss suppressing tumor development accepting optional cookies research center garcia-lora altered tumor expression metastatic melanoma correlates poor clinical response federico garrido

Questions {❓}

(2006) Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?

Schema {🗺️}

ScholarlyArticle:
      headline:Role of Altered Expression of HLA Class I Molecules in Cancer Progression
      pageEnd:131
      pageStart:123
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-72005-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Immune-Mediated Diseases
         isbn:
            978-0-387-72005-0
            978-0-387-72004-3
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Natalia Aptsiauri
            affiliation:
                  name:Hospital Universitario Virgen de las Nieves
                  address:
                     name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Teresa Cabrera
            affiliation:
                  name:Hospital Universitario Virgen de las Nieves
                  address:
                     name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rosa Mendez
            affiliation:
                  name:Hospital Universitario Virgen de las Nieves
                  address:
                     name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Angel Garcia-Lor
            affiliation:
                  name:Hospital Universitario Virgen de las Nieves
                  address:
                     name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francisco Ruiz-Cabello
            affiliation:
                  name:Hospital Universitario Virgen de las Nieves
                  address:
                     name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Federico Garrido
            affiliation:
                  name:Hospital Universitario Virgen de las Nieves
                  address:
                     name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Melanoma Cell Line, Tumor Escape, Immune Selection, Haplotype Loss, Tumor Cell Elimination
      description:HLA class I antigens play a key role in immune recognition of transformed and virally infected cells via binding to the peptides of “non-self” or aberrantly expressed proteins and subsequent presentation of the newly formed “HLA-I-peptide” complex to T lymphocytes. Consequently, a chain of immune reactions is initiated leading to tumor cell elimination by cytotoxic T cells. Altered tumor expression of HLA class I is frequently observed in various types of malignancies. It represents one of the main mechanisms used by cancer cells to evade immunosurveillance. Because of immune selection, HLA class I-negative variants escape and lead to tumor growth and metastatic colonization. Loss or downregulation of HLA class I antigens on tumor cell surface is a factor that limits clinical outcome of peptide-based cancer vaccines aimed to increasing specific anti-tumor activity of cytotoxic T lymphocytes. Thus, gaining more knowledge regarding frequency of HLA class I defect, its tissue specificity, and underlying molecular mechanisms may help designing appropriate therapeutic strategies in cancer treatment. Here, we describe various types of HLA class I alterations found in different malignancies and molecular mechanisms that underlie these defects. We also discuss a correlation between HLA class I defects cancer progression in melanoma patients with poor clinical response to autologous vaccination.
      datePublished:2007
      isAccessibleForFree:
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Book:
      name:Immune-Mediated Diseases
      isbn:
         978-0-387-72005-0
         978-0-387-72004-3
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Hospital Universitario Virgen de las Nieves
      address:
         name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
         type:PostalAddress
      name:Hospital Universitario Virgen de las Nieves
      address:
         name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
         type:PostalAddress
      name:Hospital Universitario Virgen de las Nieves
      address:
         name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
         type:PostalAddress
      name:Hospital Universitario Virgen de las Nieves
      address:
         name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
         type:PostalAddress
      name:Hospital Universitario Virgen de las Nieves
      address:
         name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
         type:PostalAddress
      name:Hospital Universitario Virgen de las Nieves
      address:
         name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Natalia Aptsiauri
      affiliation:
            name:Hospital Universitario Virgen de las Nieves
            address:
               name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
               type:PostalAddress
            type:Organization
      name:Teresa Cabrera
      affiliation:
            name:Hospital Universitario Virgen de las Nieves
            address:
               name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
               type:PostalAddress
            type:Organization
      name:Rosa Mendez
      affiliation:
            name:Hospital Universitario Virgen de las Nieves
            address:
               name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
               type:PostalAddress
            type:Organization
      name:Angel Garcia-Lor
      affiliation:
            name:Hospital Universitario Virgen de las Nieves
            address:
               name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
               type:PostalAddress
            type:Organization
      name:Francisco Ruiz-Cabello
      affiliation:
            name:Hospital Universitario Virgen de las Nieves
            address:
               name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
               type:PostalAddress
            type:Organization
      name:Federico Garrido
      affiliation:
            name:Hospital Universitario Virgen de las Nieves
            address:
               name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
      name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
      name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
      name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
      name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
      name:Departmiento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Granada, Spain
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