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Title:
CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells | SpringerLink
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Our present knowledge of how T cells eliminate cancer is mainly based on memory immune responses investigated with vaccinated mice1,2. In-vivo depletion studies with anti-CD4 monoclonal antibodies (mAb) have revealed that the antitumor immunity conferred by...
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Topics {βοΈ}
t-cell receptor-transgenic mice long-lasting anti-tumor immunity anti-class ii antibodies macrophage-activating factor produced antigen-specific cd4+ t-cell rikshospitalet-radiumhospitalet medical center month download article/chapter cell-dependent tumor rejection tumor-specific transplantation antigens tumor-capturing dendritic cells conference paper crossroads myelomas activate tumor-specific anti-cd4 monoclonal antibodies cell-dependent tumor eradication mhc class naive idiotype-specific cd4+ cells eliminate cancer murine tumor expressing privacy choices/manage cookies b-cell tumors antitumor immune response tumor cell responses perforin-mediated cytotoxicity tumor-specific antigen model tumor antigen disseminated murine leukemia paper cite device instant download tumor-specific lyt-1+2 anti-idiotypic antibodies antitumor immunity conferred differential tumor surveillance immune lymphoid cells google scholar eradicating tumor cells shape tumour immunogenicity cell clones specific single cell level immunologically specific killing european economic area eradicate pulmonary metastases epithelial malignancies effected basement membrane complexes download preview pdf idiotype-specific cd4+ dendritic cells purified phagocytic dendritic cells th2 cell clones helper cell requirement conditions privacy policy
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ScholarlyArticle:
headline:CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells
pageEnd:208
pageStart:195
image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-34814-8.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Crossroads between Innate and Adaptive Immunity
isbn:
978-0-387-34814-8
978-0-387-34813-1
type:Book
publisher:
name:Springer US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Alexandre Corthay
affiliation:
name:University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center
address:
name:Institute of Immunology, University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
type:PostalAddress
type:Organization
type:Person
keywords:Myeloma Cell, SCID Mouse, Antitumor Immunity, Tumor Rejection, Tumor Eradication
description:Our present knowledge of how T cells eliminate cancer is mainly based on memory immune responses investigated with vaccinated mice1,2. In-vivo depletion studies with anti-CD4 monoclonal antibodies (mAb) have revealed that the antitumor immunity conferred by prophylactic vaccination is usually CD4+ T cell dependent. CD4+ T cells were required for vaccination-induced immunity against the B16 melanoma3β5, against the Mc51.9 fibrosarcoma6, against the J558 plasmacytoma7, and against the A20 lymphoma7.
datePublished:2007
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name:University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center
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name:Institute of Immunology, University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
type:PostalAddress
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name:Alexandre Corthay
affiliation:
name:University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center
address:
name:Institute of Immunology, University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
type:PostalAddress
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name:Institute of Immunology, University of Oslo and Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway
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