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Title:
Mitochondrial Oscillations in Physiology and Pathophysiology | SpringerLink
Description:
Oscillations in chemical reactions and metabolic pathways have historiacally served as prototypes for understanding the dynamics of complex nonlinear systems. This chapter reviews the oscillatory behavior of mitochondria, with a focus on the mitochondrial oscillator...
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Schema {🗺️}

ScholarlyArticle:
      headline:Mitochondrial Oscillations in Physiology and Pathophysiology
      pageEnd:117
      pageStart:98
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-09794-7.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Cellular Oscillatory Mechanisms
         isbn:
            978-0-387-09794-7
            978-0-387-09793-0
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         name:Springer New York
         logo:
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            type:ImageObject
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      author:
            name:Miguel A. Aon
            affiliation:
                  name:The Johns Hopkins University
                  address:
                     name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sonia Cortassa
            affiliation:
                  name:The Johns Hopkins University
                  address:
                     name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Brian O’Rourke
            affiliation:
                  name:The Johns Hopkins University
                  address:
                     name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Reactive Oxygen Species Production, Mitochondrial Membrane Potential, Permeability Transition Pore, Mitochondrial Reactive Oxygen Species, Reactive Oxygen Species Accumulation
      description:Oscillations in chemical reactions and metabolic pathways have historiacally served as prototypes for understanding the dynamics of complex nonlinear systems. This chapter reviews the oscillatory behavior of mitochondria, with a focus on the mitochondrial oscillator dependent on reactive oxygen species (ROS), as first described in heart cells. Experimental and theoretical evidence now indicates that mitochondrial energetic variables oscillate autonomously as part of a network of coupled oscillators under both physiological and pathological conditions. The physiological domain is characterized by small-amplitude oscillations in mitochondrial membrane potential (ΔΨm) showing correlated behavior over a wide range of frequencies, as determined using Power Spectral Analysis and Relative Dispersion Analysis of long term recordings of ΔΨm. Under metabolic stress, when the balance between ROS generation and ROS scavenging is perturbed, the mitochondrial network throughout the cell locks to one main low-frequency, high-amplitude oscillatory mode. This behavior has major pathological implications because the energy dissipation and cellular redox changes that occur during ΔΨm depolarization result in suppression of electrical excitability and Ca2+ handling, the two main functions of the cardiac cell. In an ischemia/reperfusion scenario these alterations scale up to the level of the whole organ, giving rise to fatal arrhythmias.
      datePublished:2008
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      name:The Johns Hopkins University
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            address:
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               type:PostalAddress
            type:Organization
      name:Sonia Cortassa
      affiliation:
            name:The Johns Hopkins University
            address:
               name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Brian O’Rourke
      affiliation:
            name:The Johns Hopkins University
            address:
               name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
      name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
      name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
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