We are analyzing https://link.springer.com/chapter/10.1007/82_2015_478.

Title:
BTK Signaling in B Cell Differentiation and Autoimmunity | SpringerLink
Description:
Since the original identification of Bruton’s tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we...
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Keywords {🔍}

pubmed, google, scholar, cas, article, cell, kinase, tyrosine, immunol, central, mice, cells, brutons, btk, receptor, xlinked, med, exp, signaling, hendriks, xid, immunity, activation, preb, van, agammaglobulinemia, bcell, biol, immunodeficiency, antigen, arthritis, protein, domain, steinberg, witte, defect, sci, usa, nat, development, dingjan, rawlings, function, regulation, proc, natl, acad, immune, chapter, differentiation,

Topics {✒️}

lfm-a13 [alpha-cyano-beta-hydroxy-beta-methyl-n c-jun nh2-terminal kinase autoimmune c3h-gld/gld mice b-cell receptor-induced phosphorylation x-linked b-lymphocyte defect pre-b-cell receptor signalling x-linked agammaglobulinemia locus month download article/chapter defective il-5-receptor-mediated signaling enhancer-mediated chromatin interactions modified gamma-retrovirus vector restriction fragment-length polymorphism x-linked immunodeficiency phenotype extracellular signal-regulated kinase surrogate-light-chain silencing immunoglobulin subclass-specific immunodeficiency b-cell subpopulations identified congenic mrl-ipr/ipr immunoglobulin heavy-chain transcription cell receptor-mediated signaling x-linked immune defect retroviral-mediated gene transfer membrane-anchored adaptor protein synthetic double-stranded rna phospholipase c-gamma2 stabilizes b-cell receptor activation inhibits bcr-induced activation cell-activating factor receptor x-linked gene plays myeloid cell-mediated arthritis refractory mantle-cell lymphoma human x-linked agammaglobulinemia antigen receptor-intrinsic costimulation x-linked immunodeficient mice x-linked immunodeficiency genes influenza virus-infected mice grb2-btk signalling module antigen receptor-stimulated splenic systemic autoimmune disease b-cell differentiation pathway experimental murine filariosis–association beta gamma subunits de bruijn mf van loo pf tyrosine-kinase-deficient murine x-linked immunodeficient x-linked immunodeficiency tyrosine kinase induces surface immunoglobulin receptors igg-transgenic mouse line

Schema {🗺️}

ScholarlyArticle:
      headline:BTK Signaling in B Cell Differentiation and Autoimmunity
      pageEnd:105
      pageStart:67
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-26133-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:B Cell Receptor Signaling
         isbn:
            978-3-319-26133-1
            978-3-319-26131-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Odilia B. J. Corneth
            affiliation:
                  name:Erasmus MC Rotterdam
                  address:
                     name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roel G. J. Klein Wolterink
            affiliation:
                  name:Erasmus MC Rotterdam
                  address:
                     name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rudi W. Hendriks
            affiliation:
                  name:Erasmus MC Rotterdam
                  address:
                     name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:LPSLipopolysaccharide (LPS), SLE Systemic Lupus Erythematosus, Spleen Tyrosine Kinase, Collagen-induced Arthritis, influenzaInfluenza
      description:Since the original identification of Bruton’s tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial signal transducer of signals downstream of the IgM or IgG B cell antigen receptor (BCR) in mature B cells governing proliferation, survival, and differentiation. In particular, we highlight BTK function in B cells in the context of host defense and autoimmunity. Small-molecule inhibitors of BTK have very recently shown impressive anti-tumor activity in clinical studies in patients with various B cell malignancies. Since promising effects of BTK inhibition were also seen in experimental animal models for lupus and rheumatoid arthritis, BTK may be a good target for controlling autoreactive B cells in patients with systemic autoimmune disease.
      datePublished:2015
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      name:Erasmus MC Rotterdam
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      name:Erasmus MC Rotterdam
      address:
         name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
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      affiliation:
            name:Erasmus MC Rotterdam
            address:
               name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Roel G. J. Klein Wolterink
      affiliation:
            name:Erasmus MC Rotterdam
            address:
               name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Rudi W. Hendriks
      affiliation:
            name:Erasmus MC Rotterdam
            address:
               name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
      name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
      name:Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
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