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Title:
Direct Cardiac Reprogramming: Current Status and Future Prospects | SpringerLink
Description:
Advances in cellular reprogramming articulated the path for direct cardiac lineage conversion, bypassing the pluripotent state. Direct cardiac reprogramming attracts major attention because of the low or nil regenerative ability of cardiomyocytes, resulting in...
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Topics {✒️}

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Questions {❓}

Alagesan S, Griffin MD (2014) Autologous and allogeneic mesenchymal stem cells in organ transplantation: what do we know about their safety and efficacy?

Schema {🗺️}

ScholarlyArticle:
      headline:Direct Cardiac Reprogramming: Current Status and Future Prospects
      pageEnd:18
      pageStart:1
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-031-41688-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Cell Biology and Translational Medicine, Volume 20
         isbn:
            978-3-031-41688-0
            978-3-031-41687-3
         type:Book
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         name:Springer Nature Switzerland
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Krishna Kumar Haridhasapavalan
            url:https://orcid.org/0000-0003-1610-0738
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Atreyee Borthakur
            url:https://orcid.org/0000-0003-2440-1725
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rajkumar P. Thummer
            url:https://orcid.org/0000-0002-4526-8364
            affiliation:
                  name:Indian Institute of Technology Guwahati
                  address:
                     name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Cardiomyocytes, Cardiovascular diseases, Cell therapy, Direct cardiac reprogramming, Integrative and non-integrative approaches
      description:Advances in cellular reprogramming articulated the path for direct cardiac lineage conversion, bypassing the pluripotent state. Direct cardiac reprogramming attracts major attention because of the low or nil regenerative ability of cardiomyocytes, resulting in permanent cell loss in various heart diseases. In the field of cardiology, balancing this loss of cardiomyocytes was highly challenging, even in the modern medical world. Soon after the discovery of cell reprogramming, direct cardiac reprogramming also became a promising alternative for heart regeneration. This review mainly focused on the various direct cardiac reprogramming approaches (integrative and non-integrative) for the derivation of induced autologous cardiomyocytes. It also explains the advancements in cardiac reprogramming over the decade with the pros and cons of each approach. Further, the review highlights the importance of clinically relevant (non-integrative) approaches and their challenges for the prospective applications for personalized medicine. Apart from direct cardiac reprogramming, it also discusses the other strategies for generating cardiomyocytes from different sources. The understanding of these strategies could pave the way for the efficient generation of integration-free functional autologous cardiomyocytes through direct cardiac reprogramming for various biomedical applications.
      datePublished:2023
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      isbn:
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         978-3-031-41687-3
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      name:Springer Nature Switzerland
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      name:Indian Institute of Technology Guwahati
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      address:
         name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
         type:PostalAddress
      name:Indian Institute of Technology Guwahati
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         type:PostalAddress
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Person:
      name:Krishna Kumar Haridhasapavalan
      url:https://orcid.org/0000-0003-1610-0738
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Atreyee Borthakur
      url:https://orcid.org/0000-0003-2440-1725
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      name:Rajkumar P. Thummer
      url:https://orcid.org/0000-0002-4526-8364
      affiliation:
            name:Indian Institute of Technology Guwahati
            address:
               name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
      name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
      name:Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, India
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