We are analyzing https://link.springer.com/chapter/10.1007/112_2016_3.

Title:
Curcumin as a MicroRNA Regulator in Cancer: A Review | SpringerLink
Description:
Curcumin is a natural dietary polyphenol for which anti-tumor effects have been documented. Anti-inflammatory and antioxidant properties of curcumin, along with its immunomodulatory, proapoptotic, and antiangiogenic properties, are often referred to as the main...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Mirzaei H, Naseri G, Rezaee R, Mohammadi M, Banikazemi Z, Reza Mirzaei H, Salehi H, Peyvandi M, Pawelek JM, Sahebkar A (2016) Curcumin: a new candidate for melanoma therapy?
Sahebkar A (2013) Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?
Sahebkar A (2014) Are curcuminoids effective C-reactive protein-lowering agents in clinical practice?
Sahebkar A (2016) Autophagic activation: a key piece of the puzzle for the curcumin-associated cognitive enhancement?
Steger DJ, Workman JL (1996) Remodeling chromatin structures for transcription: what happens to the histones?

Schema {🗺️}

ScholarlyArticle:
      headline:Curcumin as a MicroRNA Regulator in Cancer: A Review
      pageEnd:38
      pageStart:1
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-43814-6.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
         isbn:
            978-3-319-43814-6
            978-3-319-43813-9
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         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Amir Abbas Momtazi
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fahimeh Shahabipour
            affiliation:
                  name:Pasteur Institute of Iran
                  address:
                     name:National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sepideh Khatibi
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Neurogenic Inflammation Research Center, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas P. Johnston
            affiliation:
                  name:School of Pharmacy, University of Missouri-Kansas City
                  address:
                     name:Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Matteo Pirro
            affiliation:
                  name:University of Perugia
                  address:
                     name:Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amirhossein Sahebkar
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
                  name:Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia
                  address:
                     name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Cancer, Curcumin, Epigenetics, miRNA, Turmeric
      description:Curcumin is a natural dietary polyphenol for which anti-tumor effects have been documented. Anti-inflammatory and antioxidant properties of curcumin, along with its immunomodulatory, proapoptotic, and antiangiogenic properties, are often referred to as the main mechanisms underlying the anti-tumor effects. At the molecular level, inhibition of NF-kB, Akt/PI3K, and MAPK pathways and enhancement of p53 are among the most important anticancer alterations induced by curcumin. Recent evidence has suggested that epigenetic alterations are also involved in the anti-tumor properties of curcumin. Among these curcumin-induced epigenetic alterations is modulation of the expression of several oncogenic and tumor suppressor microRNAs (miRNAs). Suppression of oncomiRs such as miR-21, miR-17-5p, miR-20a, and miR-27a and over-expression of miR-34 a/c and epithelial-mesenchymal transition-suppressor miRNAs are among the most important effects of curcumin on miRNA homeostasis. The present review will summarize the findings of in vitro and experimental studies on the impact of curcumin and its analogues on the expression of miRNAs involved in different stages of tumor initiation, growth, metastasis, and chemo-resistance.
      datePublished:2016
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Book:
      name:Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
      isbn:
         978-3-319-43814-6
         978-3-319-43813-9
Organization:
      name:Springer International Publishing
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Mashhad University of Medical Sciences
      address:
         name:Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:Pasteur Institute of Iran
      address:
         name:National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Neurogenic Inflammation Research Center, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:School of Pharmacy, University of Missouri-Kansas City
      address:
         name:Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, USA
         type:PostalAddress
      name:University of Perugia
      address:
         name:Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia
      address:
         name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
         type:PostalAddress
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Person:
      name:Amir Abbas Momtazi
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
            name:Mashhad University of Medical Sciences
            address:
               name:Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
      name:Fahimeh Shahabipour
      affiliation:
            name:Pasteur Institute of Iran
            address:
               name:National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Sepideh Khatibi
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Neurogenic Inflammation Research Center, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
      name:Thomas P. Johnston
      affiliation:
            name:School of Pharmacy, University of Missouri-Kansas City
            address:
               name:Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, USA
               type:PostalAddress
            type:Organization
      name:Matteo Pirro
      affiliation:
            name:University of Perugia
            address:
               name:Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
               type:PostalAddress
            type:Organization
      name:Amirhossein Sahebkar
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
            name:Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia
            address:
               name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
      name:National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
      name:Neurogenic Inflammation Research Center, Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, USA
      name:Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
      name:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
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