We are analyzing https://link.springer.com/chapter/10.1007/1-4020-5466-1_3.

Title:
Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1 | SpringerLink
Description:
Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic...
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Topics {✒️}

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Questions {❓}

In: Burkle A (ed) Poly(ADP-Ribosyl)ation?
PARP-1 – a perpetrator of apoptotic cell death?
Shall S, de Murcia G (2000) Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
Zhang J (2003) Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked?

Schema {🗺️}

ScholarlyArticle:
      headline:Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1
      pageEnd:72
      pageStart:45
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4020-5466-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Chromatin and Disease
         isbn:
            978-1-4020-5466-2
            978-1-4020-5465-5
         type:Book
      publisher:
         name:Springer Netherlands
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      author:
            name:David A. Wacker
            affiliation:
                  name:Cornell University
                  address:
                     name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kristine M. Frizzell
            affiliation:
                  name:Cornell University
                  address:
                     name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tong Zhang
            affiliation:
                  name:Cornell University
                  address:
                     name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
                     type:PostalAddress
                  type:Organization
            type:Person
            name:W. Lee Kraus
            affiliation:
                  name:Cornell University
                  address:
                     name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
                     type:PostalAddress
                  type:Organization
                  name:Weill Medical College of Cornell University
                  address:
                     name:Department of Pharmacology, Weill Medical College of Cornell University, New York
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Chromatin Structure, Linker Histone, Chromatin Protein, Macro Domain, Landes Bioscience
      description:Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1’s chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1’s enzymatic activity for the treatment of human diseases
      datePublished:2007
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         name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
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      address:
         name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
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      name:Kristine M. Frizzell
      affiliation:
            name:Cornell University
            address:
               name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
               type:PostalAddress
            type:Organization
      name:Tong Zhang
      affiliation:
            name:Cornell University
            address:
               name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
               type:PostalAddress
            type:Organization
      name:W. Lee Kraus
      affiliation:
            name:Cornell University
            address:
               name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
               type:PostalAddress
            type:Organization
            name:Weill Medical College of Cornell University
            address:
               name:Department of Pharmacology, Weill Medical College of Cornell University, New York
               type:PostalAddress
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      name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
      name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
      name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
      name:Department of Molecular Biology and Genetics, Cornell University, Ithaca
      name:Department of Pharmacology, Weill Medical College of Cornell University, New York
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