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Title:
Mechanisms of Tumor Evasion | SpringerLink
Description:
The results from in vitro immunological experiments, murine tumor models and patients with cancer clearly demonstrate that tumors have multiple mechanisms to evade the immune response. During the early stages of tumor development malignant cells can be poor...
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28 years and 1 months (reg. 1997-05-29).

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Topics {✒️}

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Questions {❓}

Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy?
Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

Schema {🗺️}

ScholarlyArticle:
      headline:Mechanisms of Tumor Evasion
      pageEnd:88
      pageStart:61
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-27545-1.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Tumor Immunology and Cancer Vaccines
         isbn:
            978-0-387-27545-1
            978-1-4020-8119-4
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael Campoli
            affiliation:
                  name:Roswell Park Cancer Institute
                  address:
                     name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Soldano Ferrone
            affiliation:
                  name:Roswell Park Cancer Institute
                  address:
                     name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arnold H. Zea
            affiliation:
                  name:Louisiana State University Health Sciences Center
                  address:
                     name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paulo C. Rodriguez
            affiliation:
                  name:Louisiana State University Health Sciences Center
                  address:
                     name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Augusto C. Ochoa
            affiliation:
                  name:Louisiana State University Health Sciences Center
                  address:
                     name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
                     type:PostalAddress
                  type:Organization
                  name:Louisiana State University Health Sciences Center
                  address:
                     name:Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Renal Cell Carcinoma, Cell Signal Transduction, Antigen Processing Machinery, Histocompatibility Leukocyte Antigen, Antigen Processing Machinery Component
      description:The results from in vitro immunological experiments, murine tumor models and patients with cancer clearly demonstrate that tumors have multiple mechanisms to evade the immune response. During the early stages of tumor development malignant cells can be poor stimulators, present poor targets or become resistant to the innate immune response, while at later stages, progressively growing tumors impair the adaptive immune response by blocking the maturation and function of antigen presenting cells and causing alterations in T cell signal transduction and function. Preliminary results also suggest a correlation between some of these changes and an increased metastatic potential of the tumor cells, a diminished response to immunotherapy, and poor prognosis. Carefully coordinated basic research studies and clinical immunotherapy trials will be required to fully determine the impact on the outcome of the disease and the response to treatment. However, understanding the mechanisms used by tumor cells to evade the immune system could result in new therapeutic approaches for preventing and/or reversing these immune alterations and have the potential of improving the current results of immunotherapy trials.
      datePublished:2005
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Book:
      name:Tumor Immunology and Cancer Vaccines
      isbn:
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         978-1-4020-8119-4
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      name:Springer US
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         type:ImageObject
      name:Roswell Park Cancer Institute
      address:
         name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
         type:PostalAddress
      name:Roswell Park Cancer Institute
      address:
         name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
         type:PostalAddress
      name:Louisiana State University Health Sciences Center
      address:
         name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
         type:PostalAddress
      name:Louisiana State University Health Sciences Center
      address:
         name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
         type:PostalAddress
      name:Louisiana State University Health Sciences Center
      address:
         name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
         type:PostalAddress
      name:Louisiana State University Health Sciences Center
      address:
         name:Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans
         type:PostalAddress
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Person:
      name:Michael Campoli
      affiliation:
            name:Roswell Park Cancer Institute
            address:
               name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
               type:PostalAddress
            type:Organization
      name:Soldano Ferrone
      affiliation:
            name:Roswell Park Cancer Institute
            address:
               name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
               type:PostalAddress
            type:Organization
      name:Arnold H. Zea
      affiliation:
            name:Louisiana State University Health Sciences Center
            address:
               name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
               type:PostalAddress
            type:Organization
      name:Paulo C. Rodriguez
      affiliation:
            name:Louisiana State University Health Sciences Center
            address:
               name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
               type:PostalAddress
            type:Organization
      name:Augusto C. Ochoa
      affiliation:
            name:Louisiana State University Health Sciences Center
            address:
               name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
               type:PostalAddress
            type:Organization
            name:Louisiana State University Health Sciences Center
            address:
               name:Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
      name:Department of Immunology, Roswell Park Cancer Institute, Buffalo
      name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
      name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
      name:Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans
      name:Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans
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