We are analyzing https://link.springer.com/article/10.1385/jmn:21:1:43.

Title:
Circulating TGF-β1 does not cross the intact blood-brain barrier | Journal of Molecular Neuroscience
Description:
Transforming growth factor-β (TGF-β) from the periphery can cross the disrupted blood-brain barrier (BBB) to exert neuroprotective effects on the brain. Here, we quantify its permeation across the normal mouse BBB. By high-performance liquid chromatography, we show that TGF-β1 is stable in circulating blood but does not cross the intact BBB after intravenous injection any faster than the vascular marker 99mTc-albumin. This poor rate of influx cannot be explained by rapid efflux out of the brain or lack of lipophilicity as measured by the octanol/buffer partition coefficient, although the hydrogen bonding potential was relatively high, consistent with poor penetration. Thus, the therapeutic potential of TGF-β1 administered in blood is probably limited to situations in which the BBB has been disrupted.
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Keywords {🔍}

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Topics {✒️}

blood-brain/blood-spinal cord barrier brain-derived neurotrophic factor human tgf-β1 deficiency month download article/chapter intact blood-brain barrier blood-brain barrier slowly disrupted blood-brain barrier victoria akerstrom & weihong pan vascular marker 99mtc-albumin octanol/buffer partition coefficient tyr19-melanin-concentrating hormone multiple-time regression analysis high-performance liquid chromatography blood–brain barrier blood-brain barrier tgf-beta circulating tgf-β1 molecular neuroscience aims lesioned spinal cord tgf-β1 administered full article pdf privacy choices/manage cookies drug delivery rev european economic area exert neuroprotective effects rat cerebral cortex ventricular cerebrospinal fluid tulane university school circulating blood conditions privacy policy tgf-β1 hydrogen bonding potential agouti-related protein banks article kastin accepting optional cookies tgf-β iodinated leptin crossing journal finder publish normal mouse bbb saturable transport system main content log article journal author correspondence check access instant access article log article cite intact bbb enters brain

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