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Title:
IL-17A-producing neutrophil-regulatory Tn lymphocytes | Immunologic Research
Description:
The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are γδ T cells, about 25% NKT-like cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.
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google, scholar, cas, pubmed, article, cells, immunol, cytokine, production, blood, human, interleukin, cell, factor, receptor, mice, colonystimulating, granulocyte, ley, immunity, expression, neutrophils, inflammation, exp, lymphocytes, neutrophil, research, gcsf, dendritic, clin, med, vitro, privacy, cookies, content, ilaproducing, klaus, stark, role, access, apoptotic, nat, invest, usa, monocytes, induces, distinct, csf, function, publish,
Topics {✒️}
cd18−/−p-selectin−/−double null mice p-selectin double-null mice granulocyte-macrophage colony-stimulating factors granulocyte-macrophage colony-stimulating factor vivo granulocyte-colony-stimulating factor collectively called neutrophil-regulatory granulocyte colony-stimulating factor month download article/chapter colony-stimulating factor genes il-17a-producing lymphocytes il-17a-producing cells triple-selectin-null mice lipopolysaccharide-induced airway neutrophilia csf-producing cell lines germ-free rats modified phytohemagglutinin-stimulated sorted subsets recombinant human ifn-gamma inteleukin 17-producing cd4+effector gene therapy-derived method cyclosporin a-sensitive mechanism proinflammatory cytokine il-17a delayed-type hypersensitivity responses tumor necrosis factor il-23-il-17 immune pathway il-17a-producing tn cells regulates il-17-induced cytokine release full article pdf induces autoimmune inflammation cd18 null mice regulating neutrophil production traf6-deficient mice g-csf mrna il-17-deficient mice il-23-deficient mice privacy choices/manage cookies interleukin-4 induces secretion vascular endothelial cells demetri gd g-csf secretion helper type 1 langrish cl ingested apoptotic cells impaired neutrophil mobilization apoptotic cell ingestion cytokine receptor subunit ligand-independent multimerization il-12r{beta} 1 il-17a produced express granulocyte csf
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headline:IL-17A-producing neutrophil-regulatory Tn lymphocytes
description:The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are γδ T cells, about 25% NKT-like cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.
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Neutrophil
IL-23
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headline:IL-17A-producing neutrophil-regulatory Tn lymphocytes
description:The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are γδ T cells, about 25% NKT-like cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.
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Neutrophil
IL-23
Homeostasis
Tn cells
G-CSF
Immunology
Allergology
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