Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1385/ir:34:3:229.

Title:
IL-17A-producing neutrophil-regulatory Tn lymphocytes | Immunologic Research
Description:
The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are γδ T cells, about 25% NKT-like cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

google, scholar, cas, pubmed, article, cells, immunol, cytokine, production, blood, human, interleukin, cell, factor, receptor, mice, colonystimulating, granulocyte, ley, immunity, expression, neutrophils, inflammation, exp, lymphocytes, neutrophil, research, gcsf, dendritic, clin, med, vitro, privacy, cookies, content, ilaproducing, klaus, stark, role, access, apoptotic, nat, invest, usa, monocytes, induces, distinct, csf, function, publish,

Topics {✒️}

cd18−/−p-selectin−/−double null mice p-selectin double-null mice granulocyte-macrophage colony-stimulating factors granulocyte-macrophage colony-stimulating factor vivo granulocyte-colony-stimulating factor collectively called neutrophil-regulatory granulocyte colony-stimulating factor month download article/chapter colony-stimulating factor genes il-17a-producing lymphocytes il-17a-producing cells triple-selectin-null mice lipopolysaccharide-induced airway neutrophilia csf-producing cell lines germ-free rats modified phytohemagglutinin-stimulated sorted subsets recombinant human ifn-gamma inteleukin 17-producing cd4+effector gene therapy-derived method cyclosporin a-sensitive mechanism proinflammatory cytokine il-17a delayed-type hypersensitivity responses tumor necrosis factor il-23-il-17 immune pathway il-17a-producing tn cells regulates il-17-induced cytokine release full article pdf induces autoimmune inflammation cd18 null mice regulating neutrophil production traf6-deficient mice g-csf mrna il-17-deficient mice il-23-deficient mice privacy choices/manage cookies interleukin-4 induces secretion vascular endothelial cells demetri gd g-csf secretion helper type 1 langrish cl ingested apoptotic cells impaired neutrophil mobilization apoptotic cell ingestion cytokine receptor subunit ligand-independent multimerization il-12r{beta} 1 il-17a produced express granulocyte csf

Schema {🗺️}

WebPage:
      mainEntity:
         headline:IL-17A-producing neutrophil-regulatory Tn lymphocytes
         description:The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are γδ T cells, about 25% NKT-like cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.
         datePublished:
         dateModified:
         pageStart:229
         pageEnd:242
         sameAs:https://doi.org/10.1385/IR:34:3:229
         keywords:
            IL-17
            Neutrophil
            IL-23
            Homeostasis
            Tn cells
            G-CSF
            Immunology
            Allergology
            Medicine/Public Health
            general
            Internal Medicine
         image:
         isPartOf:
            name:Immunologic Research
            issn:
               1559-0755
               0257-277X
            volumeNumber:34
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Humana Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Klaus Ley
               affiliation:
                     name:University of Virginia
                     address:
                        name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
                        type:PostalAddress
                     type:Organization
                     name:University of Virginia
                     address:
                        name:Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
                        type:PostalAddress
                     type:Organization
                     name:University of Virginia
                     address:
                        name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Emily Smith
               affiliation:
                     name:University of Virginia
                     address:
                        name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Matthew A. Stark
               affiliation:
                     name:University of Virginia
                     address:
                        name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
                        type:PostalAddress
                     type:Organization
                     name:University of Virginia
                     address:
                        name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:IL-17A-producing neutrophil-regulatory Tn lymphocytes
      description:The proinflammatory cytokine IL-17A, mainly produced by specialized T cells, plays an important homeostatic role in regulating neutrophil production and blood neutrophil counts. This review will assemble and discuss the evidence for this function of IL-17A-producing cells, which are collectively called neutrophil-regulatory T cells or Tn cells. IL-17A-producing lymphocytes are most abundant in the mesenteric lymph node, where they account for 0.15% of all lymphocytes. About 60% of the Tn cells are γδ T cells, about 25% NKT-like cells, and less than 15% are CD4 T cells. These latter cells are also known as T-17 or ThIL-17 cells, a subset of Tn cells that also plays an important role in autoimmune diseases. IL-17A produced by Tn cells regulates the production of G-CSF, which in turn promotes the proliferation of promyelocytes and maturation of neutrophils. This homeostatic mechanism plays an important role in normal physiology and in host defense against bacterial infections. This review is aimed at highlighting the important role of IL-17A-producing T cells at the interface between the adaptive and innate immune system.
      datePublished:
      dateModified:
      pageStart:229
      pageEnd:242
      sameAs:https://doi.org/10.1385/IR:34:3:229
      keywords:
         IL-17
         Neutrophil
         IL-23
         Homeostasis
         Tn cells
         G-CSF
         Immunology
         Allergology
         Medicine/Public Health
         general
         Internal Medicine
      image:
      isPartOf:
         name:Immunologic Research
         issn:
            1559-0755
            0257-277X
         volumeNumber:34
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Klaus Ley
            affiliation:
                  name:University of Virginia
                  address:
                     name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
                     type:PostalAddress
                  type:Organization
                  name:University of Virginia
                  address:
                     name:Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Virginia
                  address:
                     name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Emily Smith
            affiliation:
                  name:University of Virginia
                  address:
                     name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Matthew A. Stark
            affiliation:
                  name:University of Virginia
                  address:
                     name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
                     type:PostalAddress
                  type:Organization
                  name:University of Virginia
                  address:
                     name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Immunologic Research
      issn:
         1559-0755
         0257-277X
      volumeNumber:34
Organization:
      name:Humana Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Virginia
      address:
         name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
         type:PostalAddress
      name:University of Virginia
      address:
         name:Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
         type:PostalAddress
      name:University of Virginia
      address:
         name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
         type:PostalAddress
      name:University of Virginia
      address:
         name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
         type:PostalAddress
      name:University of Virginia
      address:
         name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
         type:PostalAddress
      name:University of Virginia
      address:
         name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Klaus Ley
      affiliation:
            name:University of Virginia
            address:
               name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
               type:PostalAddress
            type:Organization
            name:University of Virginia
            address:
               name:Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
               type:PostalAddress
            type:Organization
            name:University of Virginia
            address:
               name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Emily Smith
      affiliation:
            name:University of Virginia
            address:
               name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
               type:PostalAddress
            type:Organization
      name:Matthew A. Stark
      affiliation:
            name:University of Virginia
            address:
               name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
               type:PostalAddress
            type:Organization
            name:University of Virginia
            address:
               name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
      name:Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
      name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
      name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
      name:Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville
      name:Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(229)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.07s.