We are analyzing https://link.springer.com/article/10.1385/ir:22:2-3:137.

Title:
Immunoglobulin in the control of complement action | Immunologic Research
Description:
Complement is a critical element of innate immunity, protecting individuals from a wide variety of microbial infections. This group of proteins is responsible for many features of in flammation and tissue damage. Because of its ability to mediate autoimmune tissue damage and to destroy host tissues, it is under tight regulation with many circulating and cell-membrane-bound complement regulatory proteins. The function of much of the circulating immunoglobulin has never been defined. We have advanced the hypothesis that one function of circulating immunoglobulin is to down-regulate complernent attack on host tissues in the presence of anti-self antibody. The data to support this hypothesis are reviewed. The data are consistent with the suggestion that one mechanism of action of intravenous immunoglobulin, used to treat patients with a variety of autoimmune diseases, is prevention of complement-mediated attack on host tissues.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter complement-dependent immune damage high-dose intravenous immunoglobulin innate immunity affect complement-bacteria interactions 3b covalently bound c3bn-igg complexes intravenous immune globulin complement-mediated attack related subjects complement component c3 full article pdf human complement system privacy choices/manage cookies classical complement pathway ly-1b cells immune/idiotypic network fractionated intravenous immunoglobulin igg heavy chain human immunoglobulin preparations intravenous gamma globulin anti-complement activity european economic area regulate complernent attack mannose-binding lectin primate xeno transplantation functionally distinct lymphocytes c1 binding properties enhancing physiologic cleavage complement action published enhanced bactericidal activity guinea pig model pediat rics professor antibody-antigen aggregates anti-idiotypic suppression je volanakis check access instant access accepting optional cookies antipneumoccocal antibodies lead secrete igm autoantibodies complement system intravenous immunoglobulin article frank article log conditions privacy policy covalent binding fries lf destroy host tissues journal finder publish

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