We are analyzing https://link.springer.com/article/10.1385/ijgc:32:1:1.

Title:
The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer | Journal of Gastrointestinal Cancer
Description:
Background. Resected pancreatic cancer has a high risk of recurrence and mortality despite the the use of chemoradiotherapy. Because pancreatic cancers express tumor antigens such as carcinoembryonic antigen (CEA), it may be possible to immunize patients to induce tumor antigen-specific immune responses. We hypothesize that high-frequency tumor antigen-specific immune responses will reduce recurrence and increase survival. Autologous dendritic cells (DCs) loaded with tumor antigens are particularly potent at inducing tumor antigen-specific immune responses. Methods. Three patients with resected pancreatic adenocarcinoma following neoadjuvant chemoradiotherapy received autologous, monocyte-derived DCs loaded with the mRNA encoding CEA monthly for 6 mo. Results. It was feasible to generate an adequate number of DC from these patients and to cryopreserve them for repeated use. The DC demonstrated the typical immature phenotype. The immunizations were well-tolerated without evidence of adverse events. All three developed injection site reactivity. All three are alive without evidence of disease at more than 21/2 yr from the original diagnosis. Conclusion. The postoperative period following neoadjuvant chemoradiotherapy and pancreaticoduo-denectomy for pancreatic cancer is an ideal environment to test novel immune-based therapies. DC-based immunotherapy in this setting is safe and feasible and may lead to prolonged survival.
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article, cancer, pancreatic, pubmed, cas, google, scholar, dendritic, cells, patients, immunotherapy, cea, tumor, morse, adenocarcinoma, access, privacy, cookies, content, journal, loaded, neoadjuvant, chemoradiotherapy, nair, lyerly, antigen, responses, usa, publish, search, mrna, resection, kim, carcinoembryonic, immune, survival, autologous, peptide, int, author, data, information, log, research, gastrointestinal, safety, boczkowski, hurwitz, schlom, gilboa,

Topics {✒️}

granulocyte-macrophage colony-stimulating factors anti-ceacam6 antibody-based conjugates month download article/chapter autologous dendritic cells dendritic cells loaded recombinant ga733-2e antigen related subjects dendritic cells monocyte-derived dcs loaded article international journal gastro-intestinal carcinoma patients full article pdf dc-based immunotherapy immune-based therapies privacy choices/manage cookies carcinoembryonic antigen peptide resected pancreatic cancer gastrointestinal cancer aims brain metastases european economic area typical immature phenotype melanoma patient vaccinated tumor antigens resected pancreatic adenocarcinoma conditions privacy policy surg clin north received definitive surgery pancreatic tumor journal finder publish check access instant access article morse accepting optional cookies kim lyerly long term survival active immunotherapy article log cea mrna author correspondence pancreatic adenocarcinoma patients carcinoembryonic antigen immunological responses alan proia article cite immune activation pancreatic cancer cea peptide high risk morse ma pancreatic carcinoma

Schema {🗺️}

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         headline:The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer
         description: Background. Resected pancreatic cancer has a high risk of recurrence and mortality despite the the use of chemoradiotherapy. Because pancreatic cancers express tumor antigens such as carcinoembryonic antigen (CEA), it may be possible to immunize patients to induce tumor antigen-specific immune responses. We hypothesize that high-frequency tumor antigen-specific immune responses will reduce recurrence and increase survival. Autologous dendritic cells (DCs) loaded with tumor antigens are particularly potent at inducing tumor antigen-specific immune responses. Methods. Three patients with resected pancreatic adenocarcinoma following neoadjuvant chemoradiotherapy received autologous, monocyte-derived DCs loaded with the mRNA encoding CEA monthly for 6 mo. Results. It was feasible to generate an adequate number of DC from these patients and to cryopreserve them for repeated use. The DC demonstrated the typical immature phenotype. The immunizations were well-tolerated without evidence of adverse events. All three developed injection site reactivity. All three are alive without evidence of disease at more than 21/2 yr from the original diagnosis. Conclusion. The postoperative period following neoadjuvant chemoradiotherapy and pancreaticoduo-denectomy for pancreatic cancer is an ideal environment to test novel immune-based therapies. DC-based immunotherapy in this setting is safe and feasible and may lead to prolonged survival.
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            mRNA
            pancreatic cancer
            immunotherapy
            Oncology
            Gastroenterology
            Radiotherapy
            Cancer Research
            Internal Medicine
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      headline:The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer
      description: Background. Resected pancreatic cancer has a high risk of recurrence and mortality despite the the use of chemoradiotherapy. Because pancreatic cancers express tumor antigens such as carcinoembryonic antigen (CEA), it may be possible to immunize patients to induce tumor antigen-specific immune responses. We hypothesize that high-frequency tumor antigen-specific immune responses will reduce recurrence and increase survival. Autologous dendritic cells (DCs) loaded with tumor antigens are particularly potent at inducing tumor antigen-specific immune responses. Methods. Three patients with resected pancreatic adenocarcinoma following neoadjuvant chemoradiotherapy received autologous, monocyte-derived DCs loaded with the mRNA encoding CEA monthly for 6 mo. Results. It was feasible to generate an adequate number of DC from these patients and to cryopreserve them for repeated use. The DC demonstrated the typical immature phenotype. The immunizations were well-tolerated without evidence of adverse events. All three developed injection site reactivity. All three are alive without evidence of disease at more than 21/2 yr from the original diagnosis. Conclusion. The postoperative period following neoadjuvant chemoradiotherapy and pancreaticoduo-denectomy for pancreatic cancer is an ideal environment to test novel immune-based therapies. DC-based immunotherapy in this setting is safe and feasible and may lead to prolonged survival.
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      dateModified:
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         mRNA
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         immunotherapy
         Oncology
         Gastroenterology
         Radiotherapy
         Cancer Research
         Internal Medicine
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