We are analyzing https://link.springer.com/article/10.1385/cbb:46:1:79.

Title:
B23 and ARF | Cell Biochemistry and Biophysics
Description:
B23 (nucleophosmin/NPM) is a multifunctional protein that recently has been directly implicated in the p53 network by its documented interaction with the p14ARF/p19Arf tumor suppressor, a major upstream activator of p53. Here we provide an overview of the functional interactions of B23 and ARF. We also integrate the current models into a unified picture, showing that B23 is essential for stabilizing and maintaining a basal level of ARF in the nucleolus, whereas increasing levels of ARF after oncogenic stress promotes B23 degradation and interferes with B23 nucleocytoplasmic shuttling. In this way, ARF can be regarded as a parasitic peptide on the B23 molecule, because ARF uses this chaperone for its own survival but also antagonizes normal activities of B23. Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated.
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Keywords {🔍}

google, scholar, pubmed, cas, cell, protein, biol, nucleolar, arf, tumor, mol, suppressor, parf, article, nucleophosmin, olson, nucleophosminb, human, activity, mdm, chan, nuclear, chem, proteins, ribosomal, zhang, cancer, yung, biochem, npm, role, response, dna, sherr, genes, function, biochemistry, nucleolus, chaperone, szebeni, sci, identification, biophys, res, nature, interaction, localization, transcription, inhibits, kinase,

Topics {✒️}

tumour suppressor p53 chromatin-binding proteins month download article/chapter p14arf/p19arf tumor suppressor partially processed pre-rrna cyclin-dependent kinase 2-cyclin arf induces p53-dependent dna double-strand breaks blocking nucleo-cytoplasmic shuttling sumo-conjugating enzyme ubc9 retrovirus-mediated gene transfer growth factor-induced mitogenesis nucleolar b23 proteins nonribosomal nucleolar proteins ribosomal protein l11 major nucleolar proteins unrelated proteins capable nucleophosmin/b23 mrna delays ribosomal protein l23 uv-induced cell-killing human ribosomal dna arf tumor suppressor inhibits ribosome biogenesis ribosomal rna synthesis npm-alk fusion site tumor suppressor p53 specific complex activates rna polymerase e2f1 transcription factor privacy choices/manage cookies alternative reading frames p53-mediated apoptosis lindström & yanping zhang full article pdf p14arf promotes accumulation cell cycle arrest regulates transcriptional activity acute myelogenous leukemia nucleolar protein gene hiv-1 rev protein t-plastin genes nuclear chaperone nucleoplasmin b23 nucleocytoplasmic shuttling nuclear matrix protein swiss 3t3 fibroblasts nucleolar protein b23 nucleolar acidic protein acidic nucleolar protein manifests oncogenic activity important human factor

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         description:B23 (nucleophosmin/NPM) is a multifunctional protein that recently has been directly implicated in the p53 network by its documented interaction with the p14ARF/p19Arf tumor suppressor, a major upstream activator of p53. Here we provide an overview of the functional interactions of B23 and ARF. We also integrate the current models into a unified picture, showing that B23 is essential for stabilizing and maintaining a basal level of ARF in the nucleolus, whereas increasing levels of ARF after oncogenic stress promotes B23 degradation and interferes with B23 nucleocytoplasmic shuttling. In this way, ARF can be regarded as a parasitic peptide on the B23 molecule, because ARF uses this chaperone for its own survival but also antagonizes normal activities of B23. Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated.
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            Biological and Medical Physics
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      description:B23 (nucleophosmin/NPM) is a multifunctional protein that recently has been directly implicated in the p53 network by its documented interaction with the p14ARF/p19Arf tumor suppressor, a major upstream activator of p53. Here we provide an overview of the functional interactions of B23 and ARF. We also integrate the current models into a unified picture, showing that B23 is essential for stabilizing and maintaining a basal level of ARF in the nucleolus, whereas increasing levels of ARF after oncogenic stress promotes B23 degradation and interferes with B23 nucleocytoplasmic shuttling. In this way, ARF can be regarded as a parasitic peptide on the B23 molecule, because ARF uses this chaperone for its own survival but also antagonizes normal activities of B23. Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated.
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         nucleoplasmin
         ribosomal biogenesis
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